METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

• Published in: Molecular cancer Vol. 19; no. 1; pp. 106 - 16
• Main Authors: Chen, Xiaoxiang, Xu, Mu, Xu, Xueni, Zeng, Kaixuan, Liu, Xiangxiang, Pan, Bei, Li, Chenmeng, Sun, Li, Qin, Jian, Xu, Tao, He, Bangshun, Pan, Yuqin, Sun, Huilin, Wang, Shukui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.06.2020; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; Adenosine; Adenosine - analogs & derivatives; Adenosine - chemistry; AKT protein; Analysis; Animals; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer metastasis; Cancer treatment; Cell migration; Cell Movement; Cell Proliferation; Chromatin; Cloning; Colorectal cancer; Colorectal cancer (CRC); Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Colorectal Neoplasms - prevention & control; Demethylation; Deoxyribonucleic acid; Development and progression; DNA; DNA methylation; Experiments; Female; Gene expression; Gene Expression Regulation, Neoplastic; Histone H3; Humans; Immunoprecipitation; Lysine; Messenger RNA; Metastases; Metastasis; Methylation; Methyltransferases; Methyltransferases - genetics; Methyltransferases - metabolism; METTL14; Mice; Mice, Inbred BALB C; Mice, Nude; N6-methyladenosine; N6-methyladenosine(m6A); Neoplasm Metastasis; Prognosis; Proteins; RNA modification; RNA sequencing; SOX4; SOXC Transcription Factors - genetics; SOXC Transcription Factors - metabolism; Survival analysis; Therapeutic applications; Transcription; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; YTHDF2; China; United States > US; METTL14; YTHDF2; N6-methyladenosine(m6A); Colorectal cancer (CRC); SOX4

Colorectal cancer (CRC) is one of the leading causes of tumor-related death worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14(METTL14), a major RNA N6-adenosine methyltransferase, is involved in tumor progression via regulating RNA function. The goal of the stud...