Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19

• Published in: Free radical biology & medicine Vol. 194; pp. 308 - 315
• Main Authors: Pawelzik, Sven-Christian, Arnardottir, Hildur, Sarajlic, Philip, Mahdi, Ali, Vigor, Claire, Zurita, Javier, Zhou, Bingqing, Kolmert, Johan, Galano, Jean-Marie, Religa, Dorota, Durand, Thierry, Wheelock, Craig E., Bäck, Magnus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023; Elsevier; The Authors. Published by Elsevier Inc
• Subjects: Chromatography, Liquid; Coronavirus disease 2019 (COVID-19); COVID-19; Eicosanoids; Eicosanoids - metabolism; Emerging diseases; Emulsions; Endocrinology and metabolism; Erythrocyte oxidative stress; Fatty Acids, Omega-3; Human health and pathology; Humans; Infectious diseases; Inflammation; Isoprostanes; Life Sciences; Oxidative Stress; Pharmaceutical sciences; Pharmacology; Resolution of inflammation; Single-Blind Method; Tandem Mass Spectrometry; Isoprostanes; Eicosanoids; Inflammation; Resolution of inflammation; Erythrocyte oxidative stress; Coronavirus disease 2019 (COVID-19)

Proinflammatory bioactive lipid mediators and oxidative stress are increased in coronavirus disease 2019 (COVID-19). The randomized controlled single-blind trial COVID-Omega-F showed that intravenous omega-3 polyunsaturated fatty acids (n-3 PUFA) shifted the plasma lipid signature of COVID-19 toward...