Stimulus-dependent state transition between synchronized oscillation and randomly repetitive burst in a model cerebellar granular layer

• Published in: PLoS computational biology Vol. 7; no. 7; p. e1002087
• Main Authors: Honda, Takeru, Yamazaki, Tadashi, Tanaka, Shigeru, Nagao, Soichi, Nishino, Tetsuro
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2011; Public Library of Science (PLoS)
• Subjects: Action Potentials - physiology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - metabolism; Animals; Biology; Cerebellar Cortex - cytology; Cerebellar Cortex - metabolism; Cerebellar Cortex - physiology; Computer Simulation; Dendrites - physiology; gamma-Aminobutyric Acid - metabolism; Interneurons; Magnesium - metabolism; Models, Neurological; N-Methylaspartate - metabolism; Neurons - metabolism; Neurons - physiology; Rats; Rest - physiology; Studies; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; gamma-Aminobutyric Acid; Interneurons; Neurons; Rats; Action Potentials; Rest; Animals; Computer Simulation; Cerebellar Cortex; Dendrites; N-Methylaspartate; Magnesium; Models, Neurological

Information processing of the cerebellar granular layer composed of granule and Golgi cells is regarded as an important first step toward the cerebellar computation. Our previous theoretical studies have shown that granule cells can exhibit random alternation between burst and silent modes, which pr...