Elevated serum levels of checkpoint molecules in patients with adult Still's disease

• Published in: Arthritis research & therapy Vol. 22; no. 1; p. 174
• Main Authors: Fujita, Yuya, Asano, Tomoyuki, Matsumoto, Haruki, Matsuoka, Naoki, Temmoku, Jumpei, Sato, Shuzo, Furuya, Makiko Yashiro, Suzuki, Eiji, Watanabe, Hiroshi, Koga, Tomohiro, Kawakami, Atsushi, Migita, Kiyoshi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.07.2020; BioMed Central; BMC
• Subjects: Adult; Adult Still’s disease; Adults; Arthritis; Arthritis, Rheumatoid; Biomarkers; Cardiac patients; Care and treatment; Case-Control Studies; Checkpoint molecules; Cytokines; Enzyme-linked immunosorbent assay; Enzymes; Ferritin; Ferritins; Fever; Galectin-9; Hepatitis A Virus Cellular Receptor 2 - metabolism; Humans; Immune response; Inflammatory diseases; Interleukin-18; Interleukins; Pathogenesis; Rheumatic diseases; Rheumatoid arthritis; Rheumatoid factor; Sepsis; Somatotropin; Still's Disease, Adult-Onset; T cell immunoglobulin and mucin domain-3; T cells; T cell immunoglobulin and mucin domain-3; Galectin-9; Checkpoint molecules; Interleukin-18; Adult Still’s disease

The interaction between galectin-9 (Gal-9) and its ligand, T cell immunoglobulin, and mucin-containing-molecule-3 (TIM-3), one of the coinhibitory receptors, transduce the inhibitory signaling to regulate immune responses. The dysregulated expression of checkpoint molecules has been reported under v...