Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits

• Published in: Journal of neuroinflammation Vol. 17; no. 1; pp. 110 - 13
• Main Authors: Wu, Jing, Yang, Jian-Jun, Cao, Yan, Li, Huihui, Zhao, Hongting, Yang, Shuofei, Li, Kuanyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.04.2020; BioMed Central; BMC
• Subjects: Anesthesia; Anesthesia, General - adverse effects; Anesthetics, General - toxicity; Animal cognition; Animals; Apoptosis; Cell culture; Cell death; Cognition; Cognitive ability; Cognitive disorders; Complications and side effects; Development and progression; Divalent metal transporter-1; Ferroptosis; General anaesthesia; General anesthesia; Geriatrics; Glutamic acid receptors; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Homeostasis; Intravenous administration; Iron; Iron - metabolism; Iron metabolism disorders; Iron Overload - etiology; Iron Overload - metabolism; Iron Overload - pathology; Ketamine; Ketamine - toxicity; Laboratory animals; Male; Mice; Mice, Inbred C57BL; Mitochondria; Morphology; N-Methyl-D-aspartic acid receptors; Neurodegeneration; Neurodegenerative diseases; Neurological diseases; Neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neurotoxicity; Neurotoxicity syndromes; Neurotoxicity Syndromes - metabolism; Neurotoxicity Syndromes - pathology; Postoperative Cognitive Complications - chemically induced; Postoperative Cognitive Complications - metabolism; Postoperative Cognitive Complications - pathology; Proteins; Rats; Rats, Sprague-Dawley; Risk factors; Sevoflurane; Sevoflurane - toxicity; China; United States > US; Ferroptosis; General anaesthesia; Neurotoxicity; Cognition; Iron

Increasing evidence suggests that multiple or long-time exposure to general anaesthesia (GA) could be detrimental to cognitive development in young subjects and might also contribute to accelerated neurodegeneration in the elderly. Iron is essential for normal neuronal function, and excess iron in t...