Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits - Wu, Jing; Yang, Jian-Jun; Cao, Yan; Li, Huihui; Zhao, Hongting; Yang, Shuofei; Li, Kuanyu (Journal of neuroinflammation, 2020)
Keywords: Anesthesia; Anesthesia, General - adverse effects; Anesthetics, General - toxicity; Animal cognition; Animals; Apoptosis; Cell culture; Cell death; Cognition; Cognitive ability; Cognitive disorders; Complications and side effects; Development and progression; Divalent metal transporter-1; Ferroptosis; General anaesthesia; General anesthesia; Geriatrics; Glutamic acid receptors; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Homeostasis; Intravenous administration; Iron; Iron - metabolism; Iron metabolism disorders; Iron Overload - etiology; Iron Overload - metabolism; Iron Overload - pathology; Ketamine; Ketamine - toxicity; Laboratory animals; Male; Mice; Mice, Inbred C57BL; Mitochondria; Morphology; N-Methyl-D-aspartic acid receptors; Neurodegeneration; Neurodegenerative diseases; Neurological diseases; Neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neurotoxicity; Neurotoxicity syndromes; Neurotoxicity Syndromes - metabolism; Neurotoxicity Syndromes - pathology; Postoperative Cognitive Complications - chemically induced; Postoperative Cognitive Complications - metabolism; Postoperative Cognitive Complications - pathology; Proteins; Rats; Rats, Sprague-Dawley; Risk factors; Sevoflurane; Sevoflurane - toxicity; China; United States--US; Ferroptosis; General anaesthesia; Neurotoxicity; Cognition; Iron