Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis - Ding, Rui; Li, Haiyan; Liu, Yaqi; Ou, Weiyang; Zhang, Xifang; Chai, Huihui; Huang, Xiaofei; Yang, Weijie; Wang, Qiujing (Journal of neuroinflammation, 2022)
Keywords: Animals; Apoptosis; Blood clot; Blood clots; Caspase-1; cGAS; Cyclic GMP; Cytoplasm; Disease Models, Animal; Enzyme-linked immunosorbent assay; Experiments; Ferric chloride; Flow cytometry; Genetic aspects; Humans; IL-1β; Immunofluorescence; Immunohistochemistry; Inflammasomes; Inflammasomes - metabolism; Inflammation; Interferon; Interferons; Intranasal administration; Ischemia; Laboratory animals; Leukocytes (neutrophilic); Male; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Microglia; Microglia - metabolism; Microglia pyroptosis; Neurodegeneration; Neuroinflammation; Neuroinflammatory Diseases; Neurological diseases; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3 inflammasome; Nucleotidyltransferases - metabolism; Oxidative stress; Pathogens; Patient outcomes; Physiological aspects; Pyroptosis; RNA, Small Interfering - genetics; Signal Transduction - physiology; Sinuses; siRNA; STING; Thrombosis; Western blotting; China; United States--US; cGAS; Neuroinflammation; STING; Microglia pyroptosis; NLRP3 inflammasome