Urinary galectin-3 binding protein (G3BP) as a biomarker for disease activity and renal pathology characteristics in lupus nephritis

• Published in: Arthritis research & therapy Vol. 24; no. 1; pp. 77 - 10
• Main Authors: Ding, Huihua, Shen, Yiwei, Lin, Cheng, Qin, Ling, He, Shijun, Dai, Min, Okitsu, Shinji L., DeMartino, Julie A., Guo, Qiang, Shen, Nan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.03.2022; BioMed Central; BMC
• Subjects: Activity index; Antigens, Neoplasm - urine; Arthritis; Biomarker; Biomarkers; Biomarkers - metabolism; Biomarkers, Tumor - urine; Biopsy; Chronic kidney failure; Comparative analysis; Correlation analysis; Creatinine; Cross-Sectional Studies; Development and progression; Diagnosis; Galectin 3; Galectin-3 binding protein; Health aspects; Humans; Kidney - pathology; Kidney diseases; Lupus; Lupus nephritis; Lupus Nephritis - pathology; Nephritis; Pathology; Patients; Protein binding; Proteins; Renal biopsy; Rheumatology; Systemic lupus erythematosus; Urine; Variance analysis; China; Minneapolis Minnesota; United States > US; Biomarker; Renal biopsy; Systemic lupus erythematosus; Lupus nephritis; Activity index; Galectin-3 binding protein

There is an urgent need to identify novel biomarkers of LN to reflect renal histological changes. This study aims to investigate urinary G3BP levels in LN patients and their association with renal disease activity both clinically and pathologically. This is a cross-sectional study. A total of 119 lu...