Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration
Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxida...
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| Published in | BMC ophthalmology Vol. 20; no. 1; pp. 56 - 7 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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BioMed Central Ltd
18.02.2020
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| Abstract | Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD.
Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined.
In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L).
The d-ROMs test may provide a useful indicator of nAMD in men but not in women. |
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| AbstractList | Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 [+ or -] 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 [+ or -] 14.0 years; 10 men), and d-ROMs and BAP tests were examined. In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 [+ or -] 52.4 vs. 275.1 [+ or -] 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 [+ or -] 549 vs. 2136 [+ or -] 246 [mu]mol/L; women: 2263 [+ or -] 292 vs. 2335 [+ or -] 161 [mu]mol/L). The d-ROMs test may provide a useful indicator of nAMD in men but not in women. Abstract Background Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Methods Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. Results In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). Conclusion The d-ROMs test may provide a useful indicator of nAMD in men but not in women. Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). The d-ROMs test may provide a useful indicator of nAMD in men but not in women. Background Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Methods Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 [+ or -] 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 [+ or -] 14.0 years; 10 men), and d-ROMs and BAP tests were examined. Results In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 [+ or -] 52.4 vs. 275.1 [+ or -] 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 [+ or -] 549 vs. 2136 [+ or -] 246 [mu]mol/L; women: 2263 [+ or -] 292 vs. 2335 [+ or -] 161 [mu]mol/L). Conclusion The d-ROMs test may provide a useful indicator of nAMD in men but not in women. Keywords: Age-related macular degeneration, Diacron reactive oxygen metabolites, Biological antioxidant potential, Oxidative stress, Choroidal neovascularization Background Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. Methods Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. Results In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). Conclusion The d-ROMs test may provide a useful indicator of nAMD in men but not in women. Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD.BACKGROUNDPreviously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD.Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined.METHODSBlood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined.In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L).RESULTSIn men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L).The d-ROMs test may provide a useful indicator of nAMD in men but not in women.CONCLUSIONThe d-ROMs test may provide a useful indicator of nAMD in men but not in women. |
| ArticleNumber | 56 |
| Audience | Academic |
| Author | Kaneko, Hiroki Namba, Rina Terasaki, Hiroko Suzumura, Ayana Shimizu, Hideyuki Ito, Yasuki Tsunekawa, Taichi Kataoka, Keiko Matsuura, Toshiyuki Ito, Seina Takayama, Kei Shibata, Rei Murohara, Toyoaki |
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| Keywords | Biological antioxidant potential Oxidative stress Choroidal neovascularization Age-related macular degeneration Diacron reactive oxygen metabolites |
| Language | English |
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| Snippet | Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in... Background Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD)... Abstract Background Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular... |
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| SubjectTerms | Age Age-related macular degeneration Aged Aged, 80 and over Antioxidants Antioxidants (Nutrients) Antioxidants - metabolism Biological antioxidant potential Biomarkers - blood Care and treatment Choroidal neovascularization Choroidal Neovascularization - blood Choroidal Neovascularization - diagnosis Diacron reactive oxygen metabolites Female Fluorescein Angiography Free radicals Gender differences Humans Hypertension Macular degeneration Male Male identity Malondialdehyde Metabolites Middle Aged Neovascularization Oxidative Stress Pathogenesis Physiological aspects Reactive Oxygen Species - blood Statistical analysis Visual Acuity - physiology Wet Macular Degeneration - blood Wet Macular Degeneration - diagnosis |
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| Title | Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration |
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