Sleep and circadian rhythms in Parkinson’s disease and preclinical models

• Published in: Molecular neurodegeneration Vol. 17; no. 1; pp. 2 - 21
• Main Authors: Hunt, Jeremy, Coulson, Elizabeth J., Rajnarayanan, Rajendram, Oster, Henrik, Videnovic, Aleksandar, Rawashdeh, Oliver
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.01.2022; BioMed Central; BMC
• Subjects: Alzheimer's disease; Analysis; Animal models; Animals; Brain; circadian; Circadian Rhythm; Circadian rhythms; Electroencephalography; Eye movements; Feedback; Gene expression; Hypothalamus; Insomnia; Mice; Movement disorders; Neurodegeneration; Neurodegenerative diseases; Non-motor symptoms; Pacemakers; Parkinson Disease - diagnosis; Parkinson's disease; Physiological aspects; Physiology; REM Sleep Behavior Disorder - diagnosis; research models; Review; Sleep; sleep; circadian; RBD; research models; Non-motor symptoms; sleep behavior disorder; rapid eye movement; Parkinson’s disease; insomnia

The use of animals as models of human physiology is, and has been for many years, an indispensable tool for understanding the mechanisms of human disease. In Parkinson’s disease, various mouse models form the cornerstone of these investigations. Early models were developed to reflect the traditional...