Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis

• Published in: Molecular cancer Vol. 20; no. 1; p. 22
• Main Authors: Li, Ming-Yue, Liu, Li-Zhong, Dong, Ming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.01.2021; BioMed Central; BMC
• Subjects: Air pollution; Angiogenesis; Antitumor activity; B cells; Biocompatibility; Biodegradability; Biomarkers; Biopsy; Blood circulation; Cancer; Carcinogenesis; Care and treatment; Cell proliferation; Cell signaling; Chronic illnesses; Cigarettes; Development and progression; Diagnosis; Disease; Drug delivery; Drug delivery systems; Drug resistance; Drugs; Exosomes; Family medical history; Health aspects; Health risk assessment; Homeostasis; Immune response; Immunogenicity; Lipids; Lung cancer; Lung cancer cell-derived exosomes (LCCDEs); Medical prognosis; Metastases; Metastasis; Mortality; Pathogenesis; Physiology; Precision medicine; Prognosis; Review; Risk factors; Roles; Smoking; therapy; Tobacco smoke; Toxicity; Vehicles; diagnosis; Lung cancer cell-derived exosomes (LCCDEs); carcinogenesis; prognosis; therapy

Lung cancer is often diagnosed at an advanced stage and has a poor prognosis. Conventional treatments are not effective for metastatic lung cancer therapy. Although some of molecular targets have been identified with favorable response, those targets cannot be exploited due to the lack of suitable d...