Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques

• Published in: Retrovirology Vol. 17; no. 1; pp. 15 - 10
• Main Authors: Murata, Megumi, Yasunaga, Jun-ichirou, Washizaki, Ayaka, Seki, Yohei, Kuramitsu, Madoka, Tan, Wei Keat, Hu, Anna, Okuma, Kazu, Hamaguchi, Isao, Mizukami, Takuo, Matsuoka, Masao, Akari, Hirofumi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.06.2020; BioMed Central; BMC
• Subjects: Analysis; Animal welfare; Animals; Antibodies; Antibodies, Viral - blood; Antibody titer; Central nervous system diseases; Deltaretrovirus Infections - transmission; Deltaretrovirus Infections - veterinary; Deoxyribonucleic acid; Disease transmission; Disease Transmission, Infectious; DNA; Epidemiology; Female; Follow-Up Studies; Genetic testing; Genomes; Health aspects; Immune response (humoral); Infection; Infections; Infectious Disease Transmission, Vertical; Japan; Japanese macaques; Leukemia; Lymphocytes T; Macaca fuscata - virology; Male; Mother-to-child transmission; Plasma; Prevalence; Prevalence studies (Epidemiology); Primates; Proviral load; Proviruses - genetics; Seroconversion; Seroepidemiologic Studies; Simian T-lymphotropic virus 1 - genetics; Simian T-lymphotropic virus 1 - physiology; Spastic paraparesis; Spinal cord; STLV-1; T cells; Tropical spastic paraparesis; Zoonoses; Japan; Germany; Africa; Horizontal transmission; Prevalence; Japanese macaques; Antibody titer; STLV-1; Mother-to-child transmission; Proviral load

Simian T-cell leukemia virus type 1 (STLV-1) is disseminated among various non-human primate species and is closely related to human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. Notably, the prevale...