Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

• Published in: Molecular neurodegeneration Vol. 16; no. 1; pp. 55 - 16
• Main Authors: Bai, Bing, Vanderwall, David, Li, Yuxin, Wang, Xusheng, Poudel, Suresh, Wang, Hong, Dey, Kaushik Kumar, Chen, Ping-Chung, Yang, Ka, Peng, Junmin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.08.2021; BioMed Central; BMC
• Subjects: Advertising executives; Alzheimer Disease - etiology; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amino acids; Analysis; Astrocytes; Asymptomatic Diseases; Biomarker; Biomarkers; Blood Proteins - analysis; Cerebrospinal fluid; Cerebrospinal Fluid Proteins - analysis; Chromatography, Liquid; Cognitive Dysfunction - metabolism; Data Mining; Databases, Protein; Datasets as Topic; Dementia; Development and progression; Epithelial cells; Gene mapping; Genes; Genomics; Genotypes; Humans; Hypotheses; Ions; Labeling; Lipid metabolism; Mass spectrometry; Mass spectroscopy; Meta-analysis; Meta-Analysis as Topic; Microglia; Mitochondria; Mutation; Nerve Tissue Proteins - analysis; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurodegeneration; Neurodegenerative diseases; Oligodendrocytes; Pathogenesis; Peptides; Phenotypes; Plaque, Amyloid - chemistry; Protein Processing, Post-Translational; Proteins; Proteome; Proteomes; Proteomics; Proteomics - methods; PTM; Review; Scientific imaging; Senile plaques; Tandem Mass Spectrometry; Tau protein; United States > US; Biomarker; Abeta; Alzheimer’s disease; Amyloidome; Pathogenesis; Proteomics; PTM; Proteome; Tau; Mass spectrometry

Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer’s disease (AD). Here we review the advances and limitations in historic and recent AD proteomic research. Complementary to genetic mapping, proteomic studies not onl...