Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients

• Published in: Journal of translational medicine Vol. 19; no. 1; pp. 27 - 17
• Main Authors: Liu, Jungang, Huang, Xiaoliang, Liu, Haizhou, Wei, Chunyin, Ru, Haiming, Qin, Haiquan, Lai, Hao, Meng, Yongsheng, Wu, Guo, Xie, Weishun, Mo, Xianwei, Johnson, Caroline H., Zhang, Yawei, Tang, Weizhong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.01.2021; BioMed Central; BMC
• Subjects: Antigens, Neoplasm; C-reactive protein; Cancer therapies; CD4 antigen; Chemotherapy; Colonic Neoplasms - genetics; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Datasets; Development and progression; DNA methylation; Gene expression; Genes, ras; Genetic aspects; Genomes; Growth factors; Health aspects; Hospitals; Human subjects; Humans; Immune system; Immunoglobulin M; Immunological memory; Immunology; Immunoregulation; Immunosuppression; Immunotherapy; Inflammation; K-Ras protein; Kinases; KRAS mutation; Lymphocytes T; Macrophages; Medical prognosis; Memory cells; Metastases; Metastasis; Microenvironments; Mutants; Mutation; Mutation - genetics; NF-κB protein; Prognosis; Proteins; Proto-Oncogene Proteins p21(ras) - genetics; Proto-oncogenes; Radiation therapy; Relaxin; Ribonucleic acid; RNA; Serum levels; Signal transduction; Survival analysis; T cell receptors; Tumor Microenvironment; Tumor-infiltrating immune cells; Tumor-infiltrating lymphocytes; Tumors; China; KRAS mutation; Tumor-infiltrating immune cells; Immunosuppression; Colorectal cancer

KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). KRAS mutation-mediated regulation of immunophenotype and immune pathways in CRC remains to be elucidated. 535 CRC patients were used to compare the expression of immune-related genes (IRGs) and the abundance of tumor-...