Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing

• Published in: BMC geriatrics Vol. 22; no. 1; pp. 771 - 29
• Main Authors: Mansbart, Felix, Kienberger, Gerda, Sönnichsen, Andreas, Mann, Eva
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.09.2022; BioMed Central; BMC
• Subjects: Adrenergic alpha-1 Receptor Antagonists - adverse effects; Adrenergic alpha-Antagonists - adverse effects; Adverse events; Age; Aged; Alpha-1 antagonists; Antihypertensive Agents - therapeutic use; Antihypertensives; Benign prostatic hyperplasia; Blood pressure; Cardiovascular diseases; Care and treatment; Chlorthalidone - therapeutic use; Clinical trials; Congestive heart failure; Coronary artery disease; Doxazosin - therapeutic use; Fractures; Geriatrics; Health aspects; Heart diseases; Humans; Hyperplasia; Hypertension; Hypertension - complications; Hypertension - drug therapy; Hypertrophy; Hypotension; Inappropriate Prescribing; Intervention; Lower Urinary Tract Symptoms - drug therapy; LUTS; Male; Medication errors; Meta-analysis; Methods; Older people; Patients; Physiological aspects; Population; Prescription writing; Prevention; Prostate; Prostatic Hyperplasia - complications; Prostatic Hyperplasia - drug therapy; Quality of Life; Risk factors; Search strategies; Systematic review; Urinary tract; Vasodilation; Austria; Hypertension; Older people; Alpha-1 antagonists; Benign prostatic hyperplasia; Systematic review; LUTS; Inappropriate prescribing

Adrenergic alpha-1 receptor antagonists (alpha-1 antagonists) are frequently used medications in the management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) and in the management of therapy-resistant arterial hypertension, two conditions frequently found in...