High-Fat Diet–Induced IL-17A Exacerbates Psoriasiform Dermatitis in a Mouse Model of Steatohepatitis

• Published in: The American journal of pathology Vol. 186; no. 9; pp. 2292 - 2301
• Main Authors: Vasseur, Philippe, Serres, Laure, Jégou, Jean-François, Pohin, Mathilde, Delwail, Adriana, Petit-Paris, Isabelle, Levillain, Pierre, Favot, Laure, Samson, Michel, Yssel, Hans, Morel, Franck, Silvain, Christine, Lecron, Jean-Claude
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2016; American Society for Investigative Pathology / Elsevier
• Subjects: Animals; Dermatitis - complications; Dermatitis - pathology; Diet, High-Fat - adverse effects; Disease Models, Animal; Ecology, environment; Flow Cytometry; Fluorescent Antibody Technique; Health; Interleukin-17 - metabolism; Life Sciences; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - pathology; Pathology; Real-Time Polymerase Chain Reaction; liver-disease; il-22; risk; cytokines; innate lymphoid-cells; mice; skin inflammation

Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity o...