A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study

• Published in: Molecular cancer Vol. 21; no. 1; pp. 21 - 13
• Main Authors: Li, Kai, Lin, Yusheng, Luo, Yichen, Xiong, Xiao, Wang, Lu, Durante, Kameron, Li, Junkuo, Zhou, Fuyou, Guo, Yi, Chen, Shaobin, Chen, Yuping, Zhang, Dianzheng, Yeung, Sai-Ching Jim, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.01.2022; BioMed Central; BMC
• Subjects: Biomarkers; Biomarkers, Tumor; Biopsy; Cancer therapies; Combined Modality Therapy; Development and progression; Diagnosis; Disease Management; Endoscopy; Esophageal cancer; Esophageal carcinoma; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - etiology; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - therapy; Esophagus; Exosomes; Exosomes - metabolism; Female; Gene Expression Profiling; Hospitals; Humans; Hypoxia; Liquid-biopsy signature; Male; Metastasis; Neoplasm Grading; Neoplasm Staging; Nuclease; Pre-operative biomarker of adjuvant therapy; Prognosis; Prospective Studies; RNA sequencing; RNA, Small Untranslated - genetics; RNA, Small Untranslated - metabolism; Saliva; Saliva - metabolism; Sample size; Sensitivity and Specificity; Sequencing of salivary extracellular vesicles; Squamous cell carcinoma; Transfer RNA; Transfer RNA-derived small RNA; tRNA; tRNA-derived fragments; China; Esophageal carcinoma; Liquid-biopsy signature; Transfer RNA-derived small RNA; Pre-operative biomarker of adjuvant therapy; Sequencing of salivary extracellular vesicles; tRNA-derived fragments

The tRNA-derived small RNAs (tsRNAs) are produced in a nuclease-dependent manner in responses to variety of stresses that are common in cancers. We focus on a cancer-enriched tsRNA signature to develop a salivary exosome-based non-invasive biomarker for human esophageal squamous cell carcinoma (ESCC...