tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip

• Published in: Nucleic acids research Vol. 38; no. 15; pp. 4929 - 4945
• Main Authors: Hiura, Hitoshi, Sugawara, Atsushi, Ogawa, Hidehiko, John, Rosalind M, Miyauchi, Naoko, Miyanari, Yusuke, Horiike, Tokumasa, Li, Yufeng, Yaegashi, Nobuo, Sasaki, Hiroyuki, Kono, Tomohiro, Arima, Takahiro
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2010
• Subjects: Animals; Chromatin Immunoprecipitation; Chromosomes, Mammalian; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA Methylation; Female; Gene Regulation, Chromatin and Epigenetics; Genomic Imprinting; Humans; Immunoprecipitation; Male; Mice; Oligonucleotide Array Sequence Analysis; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism

The parent-of-origin specific expression of imprinted genes relies on DNA methylation of CpG-dinucleotides at differentially methylated regions (DMRs) during gametogenesis. To date, four paternally methylated DMRs have been identified in screens based on conventional approaches. These DMRs are linke...