Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice

• Published in: Alzheimer's research & therapy Vol. 11; no. 1; p. 88
• Main Authors: Nagy, Dávid, Martens, Lauren Herl, Leventhal, Liza, Chen, Angela, Kelley, Craig, Stoiljkovic, Milan, Hajós, Mihály
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.10.2019; BioMed Central; BMC
• Subjects: Analysis; Brain; Causes of; Dementia; Electrophysiology; Frontotemporal dementia; Genes; Genetic aspects; Nervous system diseases; Neurodegenerative diseases; Neurons; Neurophysiology; Phenotypes; Prefrontal cortex; Progranulin; Reward-seeking/processing; United States; Electrophysiology; Reward-seeking/processing; Progranulin; Prefrontal cortex; Frontotemporal dementia

Loss-of-function mutations in the progranulin gene cause frontotemporal dementia, a genetic, heterogeneous neurodegenerative disorder. Progranulin deficiency leads to extensive neuronal loss in the frontal and temporal lobes, altered synaptic connectivity, and behavioral alterations. The chronologic...