Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study

• Published in: Critical care (London, England) Vol. 26; no. 1; pp. 122 - 11
• Main Authors: Zhou, Yongfang, Yang, Jie, Wang, Bo, Wang, Peng, Wang, Zhen, Yang, Yunqin, Liang, Guopeng, jing, Xiaorong, Jin, Xiaodong, Zhang, Zhongwei, Deng, Yiyun, Hu, Chenggong, Liao, Xuelian, Yin, Wanhong, Tang, Zhihong, Tian, Yongming, Tao, Liyuan, Kang, Yan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.05.2022; BioMed Central; BMC
• Subjects: Adult; Anesthesia; Artificial respiration; Cardiac arrhythmia; Care and treatment; Critical care; Critical Illness - therapy; Critically ill; Delirium; Dexmedetomidine; Dexmedetomidine - adverse effects; Dosage and administration; Drug therapy; Drug therapy, Combination; Enrollments; Extubation; Fentanyl; Humans; Hypnotics and Sedatives - pharmacology; Hypnotics and Sedatives - therapeutic use; Hypotension; Mechanical ventilation; Methods; Midazolam; Midazolam - adverse effects; Patients; Propofol; Propofol - adverse effects; Respiration, Artificial; Sequential sedation; Ventilator weaning; Ventilators; Weaning; China; Midazolam; Propofol; Critically ill; Mechanical ventilation; Sequential sedation; Dexmedetomidine

Current sedatives have different side effects in long-term sedation. The sequential use of midazolam and dexmedetomidine for prolonged sedation may have distinct advantages. We aimed to evaluate the efficacy and safety of the sequential use of midazolam and either dexmedetomidine or propofol, and th...