MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions

• Published in: Arthritis research & therapy Vol. 22; no. 1; pp. 74 - 8
• Main Authors: Wang, Geng, Kim, Tae-Hwan, Li, Zhixiu, Cortes, Adrian, Kim, Kwangwoo, Bang, So-Young, Leo, Paul, Brown, Matthew A., Xu, Huji
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.04.2020; BioMed Central; BMC
• Subjects: Alleles; Amino acids; Analysis; Ankylosing spondylitis; Arthritis; Asian Continental Ancestry Group - genetics; Asian people; Asians; Association; China; Gene Frequency; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genomics; Genotype; HLA; HLA antigens; HLA Antigens - genetics; HLA-B27 Antigen - genetics; HLA-C Antigens - genetics; Humans; Medical research; Pathology; Polymorphism, Single Nucleotide; Republic of Korea; Spondylitis, Ankylosing - ethnology; Spondylitis, Ankylosing - genetics; Taiwan; China; Republic of Korea; Taiwan; South Korea; Asia; HLA; Ankylosing spondylitis; Association

The association of HLA-B*27 with AS is amongst the strongest of any known association of a common variant with any human disease. Nonetheless, there is strong evidence indicating that other HLA-B alleles are involved in the disease. European ethnicity studies have demonstrated risk associations with...