Lipolysis and gestational diabetes mellitus onset: a case-cohort genome-wide association study in Chinese

• Published in: Journal of translational medicine Vol. 21; no. 1; pp. 47 - 15
• Main Authors: Zhang, Miao, Li, Qing, Wang, Kai-Lin, Dong, Yao, Mu, Yu-Tong, Cao, Yan-Min, Liu, Jin, Li, Zi-Heng, Cui, Hui-Lu, Liu, Hai-Yan, Hu, An-Qun, Zheng, Ying-Jie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.01.2023; BioMed Central; BMC
• Subjects: Analysis; Beta cells; BRCA1 protein; Care and treatment; Cell proliferation; Cohort Studies; Copy number; Development and progression; Diabetes in pregnancy; Diabetes mellitus; Diabetes, Gestational - genetics; East Asian People; Energy metabolism; Female; Gene loci; Gene mapping; Genetic aspects; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genotyping; Gestational diabetes; Gestational diabetes mellitus; Glucose; Health aspects; Humans; Lipase; Lipolysis; Lipoprotein lipase; Medical records; Metabolism; Methods; Oxidoreductase; Pancreatic beta cells; Pathogenesis; Polymorphism, Single Nucleotide - genetics; Population structure; Pregnancy; Pregnant women; Quality control; Questionnaires; Risk factors; Single-nucleotide polymorphism; Values; Wnt protein; Womens health; β-Catenin; China; Gestational diabetes mellitus; Genome-wide association study; Metabolism; Lipolysis

Genetic knowledge of gestational diabetes mellitus (GDM) in Chinese women is quite limited. This study aimed to identify the risk factors and mechanism of GDM at the genetic level in a Chinese population. We conducted a genome-wide association study (GWAS) based on single nucleotide polymorphism (SN...