Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR

• Published in: NeuroImage (Orlando, Fla.) Vol. 52; no. 4; pp. 1505 - 1513
• Main Authors: Wong, Dean F., Kuwabara, Hiroto, Horti, Andrew G., Raymont, Vanessa, Brasic, James, Guevara, Maria, Ye, Weiguo, Dannals, Robert F., Ravert, Hayden T., Nandi, Ayon, Rahmim, Arman, Ming, Jeffrey E., Grachev, Igor, Roy, Christine, Cascella, Nicola
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2010; Elsevier Limited
• Subjects: Adult; Age; Brain; Brain - metabolism; Brain research; Female; Human subjects; Humans; Male; Medical imaging; Middle Aged; Piperidines - pharmacokinetics; Positron-Emission Tomography - methods; Pyrazoles - pharmacokinetics; Radiopharmaceuticals - pharmacokinetics; Receptor, Cannabinoid, CB1 - metabolism; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - metabolism; Studies; Tissue Distribution

Several studies have examined the link between the cannabinoid CB1 receptor and several neuropsychiatric illnesses, including schizophrenia. As such, there is a need for in vivo imaging tracers so that the relationship between CB1 and schizophrenia (SZ) can be further studied. In this paper, we pres...