Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respirat...

Full description

Saved in:
Bibliographic Details
Published inJournal of biomedical science Vol. 28; no. 1; p. 9
Main Authors Trougakos, Ioannis P, Stamatelopoulos, Kimon, Terpos, Evangelos, Tsitsilonis, Ourania E, Aivalioti, Evmorfia, Paraskevis, Dimitrios, Kastritis, Efstathios, Pavlakis, George N, Dimopoulos, Meletios A
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 12.01.2021
BioMed Central
BMC
Subjects
ACE2
Acute respiratory distress syndrome
Adaptive immunity
Adult respiratory distress syndrome
Age
Angiotensin II
Angiotensin-converting enzyme 2
Antigen presentation
Antigens
ARDS
Complications
Complications and side effects
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - drug therapy
COVID-19 - physiopathology
COVID-19 - virology
Cycle ratio
Cytokine storm
Cytokines
Disease transmission
Gastrointestinal system
Gastrointestinal tract
Humans
Immune response
Immune system
Infection
Infections
Inflammation
Kidneys
Life Cycle Stages
Life cycles
Organotropism
Proto-Oncogene Mas
Review
SARS-CoV-2
SARS-CoV-2 - isolation & purification
SARS-CoV-2 - physiology
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Storm damage
Tissues
TMPRSS2
Viral diseases
Viral infections
Virus diseases
Viruses
COVID-19
ACE2
TMPRSS2
SARS-CoV-2
ARDS
Online AccessGet full text

Cover

Abstract Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or other pathologies. COVID-19 is a two-phase disease being marked by (phase 1) increased virus transmission and infection rates due to the wide expression of the main infection-related ACE2, TMPRSS2 and CTSB/L human genes in tissues of the respiratory and gastrointestinal tract, as well as by (phase 2) host- and probably sex- and/or age-specific uncontrolled inflammatory immune responses which drive hyper-cytokinemia, aggressive inflammation and (due to broad organotropism of SARS-CoV-2) collateral tissue damage and systemic failure likely because of imbalanced ACE/ANGII/AT1R and ACE2/ANG(1-7)/MASR axes signaling. Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related "cytokine storm" and collateral tissue damage that triggers the severe life-threatening complications of COVID-19.
AbstractList Abstract Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or other pathologies. Main body COVID-19 is a two-phase disease being marked by ( phase 1 ) increased virus transmission and infection rates due to the wide expression of the main infection-related ACE2 , TMPRSS2 and CTSB/L human genes in tissues of the respiratory and gastrointestinal tract, as well as by ( phase 2 ) host- and probably sex- and/or age-specific uncontrolled inflammatory immune responses which drive hyper-cytokinemia, aggressive inflammation and (due to broad organotropism of SARS-CoV-2) collateral tissue damage and systemic failure likely because of imbalanced ACE/ANGII/AT1R and ACE2/ANG(1–7)/MASR axes signaling. Conclusion Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related “cytokine storm” and collateral tissue damage that triggers the severe life-threatening complications of COVID-19.
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or other pathologies. Main body COVID-19 is a two-phase disease being marked by (phase 1) increased virus transmission and infection rates due to the wide expression of the main infection-related ACE2, TMPRSS2 and CTSB/L human genes in tissues of the respiratory and gastrointestinal tract, as well as by (phase 2) host- and probably sex- and/or age-specific uncontrolled inflammatory immune responses which drive hyper-cytokinemia, aggressive inflammation and (due to broad organotropism of SARS-CoV-2) collateral tissue damage and systemic failure likely because of imbalanced ACE/ANGII/AT1R and ACE2/ANG(1-7)/MASR axes signaling. Conclusion Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related "cytokine storm" and collateral tissue damage that triggers the severe life-threatening complications of COVID-19. Keywords: ACE2, ARDS, COVID-19, SARS-CoV-2, TMPRSS2
Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or other pathologies. Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related "cytokine storm" and collateral tissue damage that triggers the severe life-threatening complications of COVID-19.
BACKGROUNDGaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or other pathologies.MAIN BODYCOVID-19 is a two-phase disease being marked by (phase 1) increased virus transmission and infection rates due to the wide expression of the main infection-related ACE2, TMPRSS2 and CTSB/L human genes in tissues of the respiratory and gastrointestinal tract, as well as by (phase 2) host- and probably sex- and/or age-specific uncontrolled inflammatory immune responses which drive hyper-cytokinemia, aggressive inflammation and (due to broad organotropism of SARS-CoV-2) collateral tissue damage and systemic failure likely because of imbalanced ACE/ANGII/AT1R and ACE2/ANG(1-7)/MASR axes signaling.CONCLUSIONHere we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related "cytokine storm" and collateral tissue damage that triggers the severe life-threatening complications of COVID-19.
Abstract Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or other pathologies. Main body COVID-19 is a two-phase disease being marked by (phase 1) increased virus transmission and infection rates due to the wide expression of the main infection-related ACE2, TMPRSS2 and CTSB/L human genes in tissues of the respiratory and gastrointestinal tract, as well as by (phase 2) host- and probably sex- and/or age-specific uncontrolled inflammatory immune responses which drive hyper-cytokinemia, aggressive inflammation and (due to broad organotropism of SARS-CoV-2) collateral tissue damage and systemic failure likely because of imbalanced ACE/ANGII/AT1R and ACE2/ANG(1–7)/MASR axes signaling. Conclusion Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related “cytokine storm” and collateral tissue damage that triggers the severe life-threatening complications of COVID-19.
Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or other pathologies. COVID-19 is a two-phase disease being marked by (phase 1) increased virus transmission and infection rates due to the wide expression of the main infection-related ACE2, TMPRSS2 and CTSB/L human genes in tissues of the respiratory and gastrointestinal tract, as well as by (phase 2) host- and probably sex- and/or age-specific uncontrolled inflammatory immune responses which drive hyper-cytokinemia, aggressive inflammation and (due to broad organotropism of SARS-CoV-2) collateral tissue damage and systemic failure likely because of imbalanced ACE/ANGII/AT1R and ACE2/ANG(1-7)/MASR axes signaling. Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related "cytokine storm" and collateral tissue damage that triggers the severe life-threatening complications of COVID-19.
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ collapse) that are triggered by COVID-19-mediated adult respiratory distress syndrome (ARDS) and/or other pathologies. Main body COVID-19 is a two-phase disease being marked by (phase 1) increased virus transmission and infection rates due to the wide expression of the main infection-related ACE2, TMPRSS2 and CTSB/L human genes in tissues of the respiratory and gastrointestinal tract, as well as by (phase 2) host- and probably sex- and/or age-specific uncontrolled inflammatory immune responses which drive hyper-cytokinemia, aggressive inflammation and (due to broad organotropism of SARS-CoV-2) collateral tissue damage and systemic failure likely because of imbalanced ACE/ANGII/AT1R and ACE2/ANG(1–7)/MASR axes signaling. Conclusion Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress viral infection rates or propagation; increase virus antigen presentation in order to activate a robust and durable adaptive immune response from the host, and/or mitigate the ARDS-related “cytokine storm” and collateral tissue damage that triggers the severe life-threatening complications of COVID-19.
ArticleNumber 9
Audience Academic
Author Pavlakis, George N
Paraskevis, Dimitrios
Trougakos, Ioannis P
Stamatelopoulos, Kimon
Terpos, Evangelos
Tsitsilonis, Ourania E
Aivalioti, Evmorfia
Dimopoulos, Meletios A
Kastritis, Efstathios
Author_xml – sequence: 1
  givenname: Ioannis P
  orcidid: 0000-0002-6179-2772
  surname: Trougakos
  fullname: Trougakos, Ioannis P
  email: itrougakos@biol.uoa.gr
  organization: Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784, Athens, Greece. itrougakos@biol.uoa.gr
– sequence: 2
  givenname: Kimon
  surname: Stamatelopoulos
  fullname: Stamatelopoulos, Kimon
  organization: Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528, Athens, Greece
– sequence: 3
  givenname: Evangelos
  surname: Terpos
  fullname: Terpos, Evangelos
  organization: Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528, Athens, Greece
– sequence: 4
  givenname: Ourania E
  surname: Tsitsilonis
  fullname: Tsitsilonis, Ourania E
  organization: Department of Animal and Human Physiology, Faculty of Biology, National and Kapodistrian University of Athens, 15784, Athens, Greece
– sequence: 5
  givenname: Evmorfia
  surname: Aivalioti
  fullname: Aivalioti, Evmorfia
  organization: Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528, Athens, Greece
– sequence: 6
  givenname: Dimitrios
  surname: Paraskevis
  fullname: Paraskevis, Dimitrios
  organization: Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 11527, Athens, Greece
– sequence: 7
  givenname: Efstathios
  surname: Kastritis
  fullname: Kastritis, Efstathios
  organization: Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528, Athens, Greece
– sequence: 8
  givenname: George N
  surname: Pavlakis
  fullname: Pavlakis, George N
  organization: Human Retrovirus Section, National Cancer Institute, Frederick, MD, 21702, USA
– sequence: 9
  givenname: Meletios A
  surname: Dimopoulos
  fullname: Dimopoulos, Meletios A
  email: mdimop@med.uoa.gr
  organization: Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528, Athens, Greece. mdimop@med.uoa.gr
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33435929$$D View this record in MEDLINE/PubMed
BookMark eNptkl2L1DAYhYusuB_6B7yQgDdebNd8tUlvhGH8GlhYcHVvQyZ928mQNmOSEUb_vOnMuu6INNCX5JwnnHDOi5PRj1AULwm-IkTWbyOhDW1KTHGJscCsrJ4UZ4RTVmJCxcmj-bQ4j3GNMakaKZ4Vp4xxVmXvWfFrMUbbr1JEyaPb2Zfbcu7vSoqc7QCZnXFwiTY6rfxmtYvWO9_vLpEeWxR0sn7Uzv6EFqUAOg0wTpiVTijp0ENC85u7xfuSNMg4O1qjHTJ-2Lg8Td74vHjaaRfhxf3_ovj28cPX-efy-ubTYj67Lk1Vs1RWpmowxlKSTnLQBEQeDSGcMykaQykVgnJBJDC6lLiiwBlgrmtCGCPNkl0UiwO39XqtNsEOOuyU11btN3zolQ7J5qxKGuhEC6IhkvCOgdZA624plxXuZCtkZr07sDbb5QCtyZmDdkfQ45PRrlTvfyghMZGCZcCbe0Dw37cQkxpsNOCcHsFvo8pJBG9qznGWvv5HuvbbkN98r5KC5kX-qnqdA9ix8_leM0HVrK5YnbPgKquu_qPKXwuDNblXnc37RwZ6MJjgYwzQPWQkWE31U4f6qVw_ta-fmkyvHr_Og-VP39hvpZfUsg
CitedBy_id crossref_primary_10_23736_S0375_9393_23_17244_0
crossref_primary_10_1007_s10787_022_01050_7
crossref_primary_10_1016_j_bmcl_2023_129238
crossref_primary_10_1093_bfgp_elad001
crossref_primary_10_1002_ajh_26406
crossref_primary_10_1109_JTEHM_2022_3208057
crossref_primary_10_2174_1381612829666221107123841
crossref_primary_10_1016_j_ijid_2022_06_035
crossref_primary_10_3390_bios13070682
crossref_primary_10_3389_fbioe_2022_780751
crossref_primary_10_3390_v15061262
crossref_primary_10_3390_vaccines9050497
crossref_primary_10_1002_mog2_58
crossref_primary_10_3389_fcimb_2023_1170505
crossref_primary_10_1007_s00403_024_02991_5
crossref_primary_10_1007_s00228_023_03486_4
crossref_primary_10_3390_antibiotics11121694
crossref_primary_10_20538_1682_0363_2023_4_164_173
crossref_primary_10_2174_0113892029291098240129113500
crossref_primary_10_1016_j_crmicr_2022_100115
crossref_primary_10_1080_10406638_2024_2318442
crossref_primary_10_1177_15353702221084966
crossref_primary_10_1007_s11224_022_02049_0
crossref_primary_10_1177_11795476231175644
crossref_primary_10_33631_sabd_1108744
crossref_primary_10_1007_s11481_021_10012_9
crossref_primary_10_1016_j_jmii_2022_04_005
crossref_primary_10_3389_fcvm_2024_1409723
crossref_primary_10_1021_acssynbio_4c00165
crossref_primary_10_1177_11779322221149622
crossref_primary_10_1007_s00418_022_02176_z
crossref_primary_10_1002_jmv_27820
crossref_primary_10_1177_10499091211046233
crossref_primary_10_1007_s42000_021_00342_x
crossref_primary_10_1038_s41467_022_33661_7
crossref_primary_10_3389_fendo_2022_879066
crossref_primary_10_3390_cells11172758
crossref_primary_10_3390_vaccines9070712
crossref_primary_10_1039_D4CP01014K
crossref_primary_10_1111_idh_12555
crossref_primary_10_1016_j_molstruc_2023_137253
crossref_primary_10_19163_2307_9266_2022_10_3_267_277
crossref_primary_10_3389_fimmu_2022_837290
crossref_primary_10_3390_microorganisms11102458
crossref_primary_10_1007_s12035_022_02932_1
crossref_primary_10_3390_microorganisms10122452
crossref_primary_10_1002_ajh_26185
crossref_primary_10_15789_2220_7619_RAR_1826
crossref_primary_10_33086_mtphj_v6i1_2768
crossref_primary_10_3390_life12060814
crossref_primary_10_3390_v15081655
crossref_primary_10_2174_1573403X18666220222144002
crossref_primary_10_3390_antibiotics13060566
crossref_primary_10_1016_j_ijpharm_2022_122421
crossref_primary_10_3390_molecules26247459
crossref_primary_10_1371_journal_pone_0266923
crossref_primary_10_1038_s42003_022_03789_9
crossref_primary_10_7180_kmj_22_114
crossref_primary_10_1186_s12860_022_00442_5
crossref_primary_10_2174_1568026623666230825094341
crossref_primary_10_1002_jmv_28481
crossref_primary_10_1186_s13045_021_01181_4
crossref_primary_10_1016_j_bbadis_2022_166393
crossref_primary_10_1186_s43055_021_00680_1
crossref_primary_10_1016_j_sciaf_2023_e01920
crossref_primary_10_1016_j_ijid_2022_09_020
crossref_primary_10_1080_01913123_2023_2286977
crossref_primary_10_3389_fendo_2023_1258646
crossref_primary_10_1186_s40035_021_00237_2
crossref_primary_10_7717_peerj_17340
crossref_primary_10_1007_s00278_023_00691_5
crossref_primary_10_1007_s11095_022_03323_w
crossref_primary_10_3390_ijms22157979
crossref_primary_10_3390_molecules28124860
crossref_primary_10_3390_biology10080733
crossref_primary_10_3390_biology11111579
crossref_primary_10_3390_ijerph19052877
crossref_primary_10_1002_14651858_CD015532
crossref_primary_10_4103_JME_JME_81_22
crossref_primary_10_3390_bios12100898
crossref_primary_10_1097_HCO_0000000000000958
crossref_primary_10_3390_jcm11123379
crossref_primary_10_3390_nu14112194
crossref_primary_10_3390_ijms23126735
crossref_primary_10_3390_nu15173802
crossref_primary_10_1007_s11010_021_04107_3
crossref_primary_10_1007_s13337_022_00793_9
crossref_primary_10_1002_rmv_2340
crossref_primary_10_1186_s12920_023_01490_2
crossref_primary_10_2174_0929867329666221004104430
crossref_primary_10_3390_vaccines11020429
crossref_primary_10_1039_D1NR07725B
crossref_primary_10_3390_jpm12111928
crossref_primary_10_1038_s41598_021_84092_1
crossref_primary_10_3389_fmicb_2022_979719
crossref_primary_10_3389_fendo_2022_880002
crossref_primary_10_1016_j_gtc_2022_09_003
crossref_primary_10_1007_s10753_022_01680_7
crossref_primary_10_1093_jac_dkad118
crossref_primary_10_1080_21655979_2023_2180221
crossref_primary_10_3390_biomedicines10040820
crossref_primary_10_3390_v16010121
crossref_primary_10_3349_ymj_2022_63_5_480
crossref_primary_10_1016_j_jddst_2022_103541
crossref_primary_10_4103_bbrj_bbrj_229_21
crossref_primary_10_1007_s11224_024_02294_5
crossref_primary_10_1080_2090598X_2021_1955554
crossref_primary_10_1016_j_jconrel_2022_05_023
crossref_primary_10_3389_fimmu_2022_1061290
crossref_primary_10_3390_ijms222111483
crossref_primary_10_1021_acs_jpcb_2c02365
crossref_primary_10_3389_fimmu_2023_1234307
crossref_primary_10_3390_ijms22168498
crossref_primary_10_3390_life12081220
crossref_primary_10_1136_postgradmedj_2021_140674
crossref_primary_10_3390_v14102314
crossref_primary_10_1002_cbic_202100186
crossref_primary_10_1007_s00705_022_05368_z
crossref_primary_10_3390_ijms25020859
crossref_primary_10_1002_mco2_254
crossref_primary_10_1002_slct_202302906
crossref_primary_10_1007_s11010_023_04845_6
crossref_primary_10_3390_vaccines9111271
crossref_primary_10_24880_maeuvfd_953646
crossref_primary_10_3389_fphar_2022_899633
crossref_primary_10_46235_1028_7221_1202_SEO
crossref_primary_10_1038_s41467_024_45193_3
crossref_primary_10_1016_j_clim_2022_109093
crossref_primary_10_1186_s13148_021_01168_5
crossref_primary_10_1089_jir_2022_0078
crossref_primary_10_1038_s41588_022_01131_x
crossref_primary_10_3390_immuno2020017
crossref_primary_10_1007_s10096_023_04627_4
crossref_primary_10_3390_cancers14153598
crossref_primary_10_3390_biom13101452
crossref_primary_10_3390_jcm11061692
crossref_primary_10_3389_fcimb_2024_1415885
crossref_primary_10_3389_fimmu_2023_1159326
crossref_primary_10_1016_j_vacune_2024_05_002
crossref_primary_10_21518_ms2023_261
crossref_primary_10_1016_j_molmed_2022_04_007
crossref_primary_10_1016_j_mran_2023_100280
crossref_primary_10_2174_2666796703666220623090158
crossref_primary_10_1186_s42269_022_00945_3
crossref_primary_10_1186_s43045_023_00376_4
crossref_primary_10_4014_jmb_2206_06064
crossref_primary_10_1016_j_jiph_2022_11_022
crossref_primary_10_1021_acs_jcim_2c01352
crossref_primary_10_1186_s12916_021_02090_6
crossref_primary_10_3389_fimmu_2022_862522
crossref_primary_10_53696_27214834_733
crossref_primary_10_3390_neurolint15030056
crossref_primary_10_15789_1563_0625_SRO_2613
crossref_primary_10_1016_j_vacun_2024_01_001
crossref_primary_10_1007_s11224_022_01996_y
crossref_primary_10_1002_jmv_27762
crossref_primary_10_1021_acs_jafc_3c00285
crossref_primary_10_3390_molecules27238251
crossref_primary_10_3390_biomedicines11082123
crossref_primary_10_3390_ijms23031182
crossref_primary_10_3390_cancers14112796
crossref_primary_10_3390_ijms23073984
crossref_primary_10_1155_2022_8124673
crossref_primary_10_1177_1721727X221125436
crossref_primary_10_1016_j_jgr_2022_09_010
crossref_primary_10_1016_j_ajem_2023_11_044
Cites_doi 10.1056/NEJMoa2007764
10.1016/j.stem.2020.10.001
10.3390/antiox9070595
10.1111/tra.12119
10.1182/blood.2020006520
10.1007/s00415-020-09929-7
10.1038/s41586-020-2588-y
10.1038/ki.2014.274
10.1016/j.pharmthera.2020.107587
10.1038/s41467-020-17972-1
10.1128/JVI.02232-10
10.1161/HYPERTENSIONAHA.120.15622
10.1126/science.abb4489
10.1038/s41586-020-2349-y
10.1128/JVI.01792-08
10.1016/j.chom.2016.01.007
10.1136/gutjnl-2020-321434
10.1016/j.coph.2006.03.001
10.1038/d41586-020-03166-8
10.1038/s41586-020-2558-4
10.1016/S0140-6736(20)30183-5
10.1038/nm1267
10.1038/d41586-020-03248-7
10.1038/s41591-020-0820-9
10.1038/s41586-020-2639-4
10.1186/1743-422X-11-40
10.1038/s41586-020-2538-8
10.1038/s41586-020-2575-3
10.1016/j.lfs.2020.117592
10.1183/09031936.00186214
10.1038/s41591-020-1038-6
10.1126/science.abb7498
10.1016/j.ijid.2020.06.006
10.1016/bs.ircmb.2014.09.002
10.1186/s12989-015-0080-x
10.1126/science.abb0762
10.1016/j.encep.2020.05.006
10.1126/science.370.6517.642
10.1056/NEJMc2011400
10.1007/s40264-015-0371-z
10.1111/tra.12425
10.1126/science.abe8499
10.1038/s41586-020-2332-7
10.1042/CS20120461
10.1126/science.abc8511
10.1128/AAC.00754-20
10.1126/science.abc5902
10.1016/j.febslet.2006.06.029
10.1042/BSR20201256
10.1126/science.abb3405
10.1016/S0140-6736(20)30937-5
10.1126/science.abc6284
10.1038/s41587-020-0631-z
10.1113/expphysiol.2007.040345
10.1056/NEJMoa2021436
10.1186/s40001-020-00454-x
10.1038/s41586-020-2608-y
10.1016/j.cell.2020.09.038
10.1016/j.cell.2020.06.043
10.1038/s41586-020-2622-0
10.1126/science.abc1669
10.1136/bmj.m1849
10.1126/science.abc2241
10.1016/S2665-9913(20)30173-9
10.1126/science.abd0831
10.1016/j.dsx.2020.06.047
10.1016/j.cell.2020.04.026
10.1016/j.archger.2012.05.007
10.1016/j.niox.2020.06.002
10.7554/eLife.61390
10.1038/s41586-020-2814-7
10.1016/j.cell.2020.06.035
10.2174/092986706777935122
10.3389/fonc.2019.00852
10.1038/d41586-020-01221-y
10.1038/s41591-020-0868-6
10.1161/CIRCRESAHA.116.307708
10.1016/j.redox.2020.101615
10.1126/science.abb8925
10.1016/j.phrs.2017.06.005
10.1016/j.chom.2020.04.009
10.1038/s41586-020-2598-9
10.1016/j.ijantimicag.2020.105938
10.1016/j.xcrm.2020.100016
10.1056/NEJMoa2006923
10.1186/s13054-017-1823-x
10.1038/s41586-020-2380-z
10.1038/nature11228
10.1056/NEJMoa2026920
10.1038/s41586-020-2607-z
10.1038/s41586-020-2196-x
10.1002/jcp.29785
10.1126/science.abc0870
10.1126/science.abe3354
10.1016/j.cell.2020.06.011
10.1016/j.coi.2018.04.014
10.1016/j.cmet.2020.11.005
10.1038/nature03712
10.1038/s41586-020-2599-8
10.1056/NEJMoa2029849
10.1016/j.cell.2020.02.052
10.1001/jama.2020.17022
10.1002/ajh.25829
10.1126/science.abd4570
10.1371/journal.ppat.1008536
10.1001/jama.2020.17021
10.1016/j.cell.2020.05.025
10.3390/antiox9080659
10.1016/j.cell.2020.08.028
10.1016/j.cell.2020.07.012
10.1016/j.ijantimicag.2020.105944
10.2165/00002512-200016020-00005
10.1126/science.368.6489.356
10.1038/s41586-020-2180-5
10.1136/bmj.m1252
10.15252/embj.2020106057
10.1101/2020.06.07.137802
10.1002/eji.201445272
10.1253/circj.CJ-10-0045
10.1126/science.abc7520
10.1093/ibd/izaa114
10.1073/pnas.2002589117
10.1038/s41586-020-2700-3
10.21203/rs.3.rs-48659/v1
10.1126/science.abc6952
10.1111/bcpt.13533
10.1038/s41586-020-2550-z
10.1080/22221751.2020.1732837
10.1101/2020.05.12.091082
10.1056/NEJMoa2007016
10.1038/s41586-020-2895-3
10.1016/j.bbrc.2020.09.042
10.1016/j.ejmech.2014.09.051
10.1016/j.cell.2020.07.024
10.1053/j.gastro.2020.05.065
10.1177/2047487319893042
10.3201/eid2607.200839
10.1097/CCE.0000000000000284
10.1161/HYPERTENSIONAHA.120.15572
10.1111/1440-1681.12137
10.1007/s10557-018-06847-9
10.1038/s41586-020-2312-y
10.1111/jgh.15047
10.1038/s41586-020-2355-0
10.1016/j.cmet.2020.11.006
10.1038/s41591-020-0944-y
10.26402/jpp.2020.2.01
10.15252/embj.2020106230
10.1136/jitc-2020-001089
10.1016/j.mce.2008.09.020
10.5582/ddt.2020.01017
10.1126/science.abc1932
10.1016/j.cell.2020.04.004
10.1038/d41586-020-02483-2
10.1001/jamanetworkopen.2020.13136
10.1126/science.abe2402
10.1038/s41591-020-1021-2
10.1128/JVI.00998-13
10.1038/s41392-020-00373-7
10.1038/s41586-020-2381-y
10.1016/j.fct.2020.111639
10.1111/j.1365-2249.2004.02415.x
10.1038/s41586-020-2368-8
10.1126/science.abd0827
10.1038/s41591-020-1048-4
10.1038/s41591-020-0912-6
10.1126/science.abd4585
10.1007/s11906-014-0512-2
10.1126/science.abc7424
10.1016/S1665-2681(19)32118-0
10.1126/science.369.6501.238
10.1016/j.ijantimicag.2020.105949
10.1136/bmj.m2263
10.1016/j.jinf.2020.03.002
10.1080/22221751.2020.1743767
10.1038/s41586-020-2548-6
10.1016/j.molcel.2020.04.022
10.1002/14651858.CD000284.pub3
10.1016/j.cell.2020.06.008
10.1074/jbc.M002615200
10.1161/01.RES.87.5.e1
10.1038/s41591-020-1088-9
10.1038/s41591-020-0998-x
ContentType Journal Article
Copyright COPYRIGHT 2021 BioMed Central Ltd.
2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2021
Copyright_xml – notice: COPYRIGHT 2021 BioMed Central Ltd.
– notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2021
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7QL
7QO
7QP
7T5
7TK
7TM
7U7
7U9
7X7
7XB
88E
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
8G5
ABJCF
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
COVID
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
L6V
LK8
M0S
M1P
M2O
M7N
M7P
M7S
MBDVC
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
PTHSS
Q9U
RC3
7X8
5PM
DOA
DOI 10.1186/s12929-020-00703-5
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
Materials Science & Engineering Collection
ProQuest Central (Alumni Edition)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
Coronavirus Research Database
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Engineering Collection
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
ProQuest research library
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
Publicly Available Content (ProQuest)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Engineering Collection
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
ProQuest Medical Library (Alumni)
Engineering Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Coronavirus Research Database
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Technology Collection
Technology Research Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Central
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
ProQuest Research Library
ProQuest Central Basic
Toxicology Abstracts
ProQuest SciTech Collection
ProQuest Medical Library
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef


MEDLINE - Academic

MEDLINE
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1423-0127
EndPage 9
ExternalDocumentID oai_doaj_org_article_8cef7de791814f3eaae26fb8b50f8d78
A653679105
10_1186_s12929_020_00703_5
33435929
Genre Journal Article
Review
GroupedDBID ---
-A0
.86
0R~
29J
29K
2NJ
2WC
36B
3V.
4.4
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
AAFWJ
ABDBF
ABJCF
ABOCM
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACPRK
ACRMQ
ADBBV
ADIMF
ADINQ
ADRAZ
ADUKV
AEAQA
AEGNC
AENEX
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
AZQEC
B0M
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BGLVJ
BGNMA
BHPHI
BMC
BPHCQ
BVXVI
C24
C6C
CCPQU
CGR
CS3
CUY
CVF
CYUIP
D-I
DIK
DU5
DWQXO
E3Z
EAD
EAP
EBC
EBD
EBLON
EBS
ECM
EIF
EMB
EMK
EMOBN
EPL
ESX
F5P
FYUFA
GNUQQ
GROUPED_DOAJ
GUQSH
GX1
HCIFZ
HMCUK
HYE
IAO
IEA
IHE
IHR
INH
INR
ITC
IZQ
KDC
KQ8
L6V
LAK
LK8
M1P
M2O
M48
M4Y
M7P
M7S
ML~
M~E
NPM
NU0
O5R
O5S
OK1
P19
P2P
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
RBZ
RHV
RNS
ROL
RPM
RPX
RRX
RSV
S27
SBL
SDH
SOJ
SV3
T13
TR2
TUS
UKHRP
VC2
WJK
WK8
~8M
~KM
AAYXX
CITATION
53G
ABVAZ
AFGXO
AFNRJ
SBY
7QL
7QO
7QP
7T5
7TK
7TM
7U7
7U9
7XB
8FD
8FK
C1K
COVID
FR3
H94
K9.
M7N
MBDVC
P64
PQEST
PQUKI
PRINS
Q9U
RC3
7X8
5PM
ID FETCH-LOGICAL-c563t-5c59000881f84ea1e7881c11443879c2227724718e32b8052e43e04a6113319b3
IEDL.DBID RPM
ISSN 1423-0127
1021-7770
IngestDate Thu Sep 05 15:45:17 EDT 2024
Tue Sep 17 21:22:24 EDT 2024
Fri Aug 16 23:22:52 EDT 2024
Fri Sep 13 02:12:56 EDT 2024
Thu Feb 22 23:59:21 EST 2024
Fri Feb 02 04:30:20 EST 2024
Thu Sep 12 18:14:58 EDT 2024
Sat Sep 28 08:21:13 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords COVID-19
ACE2
TMPRSS2
SARS-CoV-2
ARDS
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c563t-5c59000881f84ea1e7881c11443879c2227724718e32b8052e43e04a6113319b3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0002-6179-2772
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801873/
PMID 33435929
PQID 2478728721
PQPubID 54111
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_8cef7de791814f3eaae26fb8b50f8d78
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7801873
proquest_miscellaneous_2477496440
proquest_journals_2478728721
gale_infotracmisc_A653679105
gale_infotracacademiconefile_A653679105
crossref_primary_10_1186_s12929_020_00703_5
pubmed_primary_33435929
PublicationCentury 2000
PublicationDate 2021-01-12
PublicationDateYYYYMMDD 2021-01-12
PublicationDate_xml – month: 01
  year: 2021
  text: 2021-01-12
  day: 12
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Basel
– name: London
PublicationTitle Journal of biomedical science
PublicationTitleAlternate J Biomed Sci
PublicationYear 2021
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References X Chen (703_CR182) 2019; 9
D Tang (703_CR20) 2020; 16
Z Zhou (703_CR49) 2020; 267
E Callaway (703_CR67) 2020
VG Puelles (703_CR31) 2020
JH Beigel (703_CR98) 2020
E Mahase (703_CR3) 2020; 368
MM Lamers (703_CR36) 2020
J Hansen (703_CR73) 2020
M Hoffmann (703_CR181) 2020; 64
W Chen (703_CR35) 2020; 9
H Wang (703_CR58) 2020; 182
A Khan (703_CR167) 2017; 21
N Alenina (703_CR119) 2008; 93
NN Zhang (703_CR151) 2020; 182
S Wu (703_CR150) 2020; 11
703_CR9
G Mancia (703_CR22) 2020
C Keech (703_CR65) 2020
C Rydyznski Moderbacher (703_CR133) 2020; 183
CA Devaux (703_CR102) 2020
M Donoghue (703_CR13) 2000; 87
T Yoshikawa (703_CR28) 2009; 83
PJM Brouwer (703_CR68) 2020
S Matsuyama (703_CR89) 2020; 117
H Su (703_CR32) 2020; S0085–2538
C Iadecola (703_CR52) 2020; 183
P Breining (703_CR87) 2020
SJ Zost (703_CR155) 2020
M Blignaut (703_CR103) 2019; 33
L Zhang (703_CR95) 2020
A Shamsi (703_CR187) 2020; 40
RI Okonkwo (703_CR189) 2016; 39
R Wölfel (703_CR33) 2020
D Pinto (703_CR70) 2020
EJ Giamarellos-Bourboulis (703_CR128) 2020
The RECOVERY Collaborative Group (703_CR135) 2020
J Braun (703_CR137) 2020
P Zhong (703_CR43) 2020; 5
SR Tipnis (703_CR14) 2000; 275
AO Hassan (703_CR80) 2020; 182
E Terpos (703_CR122) 2020
J Lan (703_CR5) 2020
XC Li (703_CR15) 2017; 125
M Hoffmann (703_CR6) 2020
A Mareti (703_CR108) 2019
J Cohen (703_CR100) 2020; 370
E Callaway (703_CR66) 2020; 587
J Wu (703_CR195) 2020; 102
E Callaway (703_CR55) 2020; 580
Y Imai (703_CR12) 2010; 74
SR Bonam (703_CR127) 2020
L Dai (703_CR149) 2020; 182
N Le Bert (703_CR136) 2020; 584
DM Bennion (703_CR118) 2015; 17
L Chang (703_CR34) 2020
KS Corbett (703_CR60) 2020
703_CR186
703_CR180
X Guo (703_CR202) 2020; 76
Y Cao (703_CR74) 2020; 182
A Sharma (703_CR42) 2020; S1665–2681
M Hoffmann (703_CR4) 2020; 8674
P Mendonca (703_CR194) 2020; 9
Q Gao (703_CR56) 2020
M Plaze (703_CR185) 2020; 46
T Hashimoto (703_CR16) 2012; 487
X Zhang (703_CR134) 2020
IK Cheah (703_CR197) 2020; 9
ZH Wu (703_CR41) 2020; 25
GH Marin (703_CR21) 2020
CW Tan (703_CR83) 2020; 38
H Hofmann-Winkler (703_CR86) 2020; 2
Y Imai (703_CR25) 2005; 436
D Mathew (703_CR124) 2020; 369
L Deng (703_CR183) 2020; 81
A Ramani (703_CR50) 2020
NB Mercado (703_CR61) 2020
G Guaraldi (703_CR198) 2020; 2
V Ramlall (703_CR123) 2020
AA Elfiky (703_CR97) 2020
I Kusmartseva (703_CR46) 2020
M Wadman (703_CR54) 2020; 368
J Grein (703_CR99) 2020
CGK Ziegler (703_CR19) 2020; 181
MA Tortorici (703_CR77) 2020
C Huang (703_CR1) 2020; 395
C Sumners (703_CR47) 2013; 40
K Zhang (703_CR115) 2015; 87
FL Stratford (703_CR113) 2006; 580
R Pranata (703_CR201) 2020; 14
B Ju (703_CR69) 2020
C Lucas (703_CR125) 2020; 584
MJ Mulligan (703_CR63) 2020
K Kuba (703_CR23) 2005; 11
L Bao (703_CR24) 2020
L Cantuti-Castelvetri (703_CR7) 2020
SR Elkin (703_CR90) 2016; 17
W Sungnak (703_CR18) 2020
S Mallapaty (703_CR145) 2020; 585
KC Coate (703_CR45) 2020
R Kaur (703_CR101) 2014; 87
AO Adedeji (703_CR85) 2013; 87
AM Arvin (703_CR156) 2020; 584
R Frlan (703_CR106) 2006; 13
JA Plante (703_CR139) 2020
F Zhou (703_CR200) 2020; 76
N van Doremalen (703_CR62) 2020
D Blanco-Melo (703_CR129) 2020
Z Anna (703_CR154) 2020; 369
T Liu (703_CR169) 2020; 213
P Bastard (703_CR131) 2020
W Tang (703_CR105) 2020; 369
P Gautret (703_CR192) 2020; 56
S Abdulla (703_CR44) 2020; 12
A Baum (703_CR75) 2020; 369
H Al-Samkari (703_CR121) 2020
SG Deftereos (703_CR191) 2020; 3
K Kuba (703_CR10) 2006; 6
HS Hillen (703_CR96) 2020
AJ Wilk (703_CR130) 2020
A Wyczałkowska-Tomasik (703_CR107) 2012; 55
T Takahashi (703_CR144) 2020
S Wang (703_CR93) 2020; 39
703_CR176
703_CR177
SH Sun (703_CR40) 2020; S1931–3128
A Baum (703_CR76) 2020; 370
J Zhou (703_CR39) 2020
KM Edwards (703_CR152) 2020
703_CR170
703_CR171
STH Liu (703_CR147) 2020
ML Shiffman (703_CR188) 2004; 3
DC Angus (703_CR160) 2020
Z Varga (703_CR120) 2020; 395
D Dworakowska (703_CR203) 2020
Y Sun (703_CR26) 2015; 12
U Sahin (703_CR64) 2020
M Lindauer (703_CR179) 2018; 212
N Khan (703_CR174) 2020
SJ Zost (703_CR79) 2020; 584
BM Tomazini (703_CR161) 2020
703_CR165
703_CR166
703_CR168
703_CR162
703_CR163
703_CR164
JB Moore (703_CR53) 2020
R Channappanavar (703_CR30) 2016; 19
I Glowacka (703_CR88) 2011; 85
V Monteil (703_CR84) 2020
A McCluskey (703_CR91) 2013; 14
DL Weir (703_CR92) 2014; 11
A Tursi (703_CR175) 2020; 26
VB Patel (703_CR117) 2016; 118
Z Ghazizadeh (703_CR172) 2020
V Montesarchio (703_CR199) 2020; 8
TF Rogers (703_CR71) 2020
NZ Cuervo (703_CR8) 2020; 9
Q Zhang (703_CR132) 2020
SM Bindom (703_CR11) 2009; 302
J Yu (703_CR57) 2020
E Finzi (703_CR196) 2020; 99
AN Akbar (703_CR146) 2020; 369
E Buscarini (703_CR37) 2020
D Bojkova (703_CR114) 2020
K Kupferschmidt (703_CR138) 2020; 369
LJ Scott (703_CR178) 2000; 16
B Korber (703_CR141) 2020; 182
W Dai (703_CR94) 2020
D Zanker (703_CR111) 2014; 44
AG Laing (703_CR126) 2020
P Chen (703_CR81) 2020
B Yousefi (703_CR190) 2020
JM Hirshburg (703_CR173) 2016; 9
E Gkogkou (703_CR17) 2020; 36
YJ Hou (703_CR140) 2020
CW Keller (703_CR109) 2018; 52
I Torjesen (703_CR104) 2020; 369
DG Passos-Silva (703_CR116) 2013; 124
KG Andersen (703_CR110) 2020; 26
L Pellegrini (703_CR51) 2020; 27
J Jianhui Nie (703_CR82) 2020; 9
SA Baron (703_CR193) 2020; 55
X Chi (703_CR153) 2020
D Javorac (703_CR184) 2020; 144
E Terpos (703_CR148) 2020; 383
CK Wong (703_CR27) 2004; 136
SH Wong (703_CR38) 2020
DM Bennion (703_CR48) 2015; 17
S Herold (703_CR29) 2015; 45
KK Chan (703_CR157) 2020; 369
R Shi (703_CR72) 2020
Y Wu (703_CR78) 2020; 368
Y Gao (703_CR2) 2020; 368
EN Tsakiri (703_CR112) 2015; 314
Q Li (703_CR142) 2020; 182
P Maisonnasse (703_CR158) 2020
P Brest (703_CR143) 2020; S0168–9525
M Hoffmann (703_CR159) 2020
J Yang (703_CR59) 2020
References_xml – year: 2020
  ident: 703_CR98
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2007764
  contributor:
    fullname: JH Beigel
– volume: 9
  start-page: 56
  year: 2016
  ident: 703_CR173
  publication-title: J Clin Aesthet Dermatol
  contributor:
    fullname: JM Hirshburg
– volume: 27
  start-page: 951
  year: 2020
  ident: 703_CR51
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.10.001
  contributor:
    fullname: L Pellegrini
– volume: 9
  start-page: 595
  year: 2020
  ident: 703_CR197
  publication-title: Antioxidants (Basel)
  doi: 10.3390/antiox9070595
  contributor:
    fullname: IK Cheah
– ident: 703_CR162
– volume: 14
  start-page: 1272
  year: 2013
  ident: 703_CR91
  publication-title: Traffic
  doi: 10.1111/tra.12119
  contributor:
    fullname: A McCluskey
– year: 2020
  ident: 703_CR121
  publication-title: Blood
  doi: 10.1182/blood.2020006520
  contributor:
    fullname: H Al-Samkari
– volume: 267
  start-page: 2179
  issue: 8
  year: 2020
  ident: 703_CR49
  publication-title: J Neurol
  doi: 10.1007/s00415-020-09929-7
  contributor:
    fullname: Z Zhou
– volume: S0085–2538
  start-page: 30369
  issue: 20
  year: 2020
  ident: 703_CR32
  publication-title: Kidney Int
  contributor:
    fullname: H Su
– volume: 584
  start-page: 463
  year: 2020
  ident: 703_CR125
  publication-title: Nature
  doi: 10.1038/s41586-020-2588-y
  contributor:
    fullname: C Lucas
– volume: 87
  start-page: 359
  year: 2015
  ident: 703_CR115
  publication-title: Kidney Int
  doi: 10.1038/ki.2014.274
  contributor:
    fullname: K Zhang
– volume: 213
  start-page: 107587
  year: 2020
  ident: 703_CR169
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2020.107587
  contributor:
    fullname: T Liu
– volume: 11
  start-page: 4081
  year: 2020
  ident: 703_CR150
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-17972-1
  contributor:
    fullname: S Wu
– volume: 85
  start-page: 4122
  year: 2011
  ident: 703_CR88
  publication-title: J Virol
  doi: 10.1128/JVI.02232-10
  contributor:
    fullname: I Glowacka
– volume: 76
  start-page: e15
  year: 2020
  ident: 703_CR200
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.120.15622
  contributor:
    fullname: F Zhou
– year: 2020
  ident: 703_CR94
  publication-title: Science
  doi: 10.1126/science.abb4489
  contributor:
    fullname: W Dai
– year: 2020
  ident: 703_CR70
  publication-title: Nature
  doi: 10.1038/s41586-020-2349-y
  contributor:
    fullname: D Pinto
– volume: 83
  start-page: 3039
  year: 2009
  ident: 703_CR28
  publication-title: J Virol
  doi: 10.1128/JVI.01792-08
  contributor:
    fullname: T Yoshikawa
– volume: 19
  start-page: 181
  year: 2016
  ident: 703_CR30
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.01.007
  contributor:
    fullname: R Channappanavar
– year: 2020
  ident: 703_CR37
  publication-title: Gut
  doi: 10.1136/gutjnl-2020-321434
  contributor:
    fullname: E Buscarini
– volume: 6
  start-page: 271
  year: 2006
  ident: 703_CR10
  publication-title: Curr Opin Pharmacol
  doi: 10.1016/j.coph.2006.03.001
  contributor:
    fullname: K Kuba
– year: 2020
  ident: 703_CR67
  publication-title: Nature
  doi: 10.1038/d41586-020-03166-8
  contributor:
    fullname: E Callaway
– year: 2020
  ident: 703_CR158
  publication-title: Nature
  doi: 10.1038/s41586-020-2558-4
  contributor:
    fullname: P Maisonnasse
– volume: 395
  start-page: 497
  year: 2020
  ident: 703_CR1
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30183-5
  contributor:
    fullname: C Huang
– volume: 11
  start-page: 875
  year: 2005
  ident: 703_CR23
  publication-title: Nat Med
  doi: 10.1038/nm1267
  contributor:
    fullname: K Kuba
– volume: 587
  start-page: 337
  issue: 7834
  year: 2020
  ident: 703_CR66
  publication-title: Nature
  doi: 10.1038/d41586-020-03248-7
  contributor:
    fullname: E Callaway
– volume: 26
  start-page: 450
  year: 2020
  ident: 703_CR110
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0820-9
  contributor:
    fullname: KG Andersen
– year: 2020
  ident: 703_CR63
  publication-title: Nature
  doi: 10.1038/s41586-020-2639-4
  contributor:
    fullname: MJ Mulligan
– volume: 11
  start-page: 40
  year: 2014
  ident: 703_CR92
  publication-title: Virol J
  doi: 10.1186/1743-422X-11-40
  contributor:
    fullname: DL Weir
– volume: 584
  start-page: 353
  year: 2020
  ident: 703_CR156
  publication-title: Nature
  doi: 10.1038/s41586-020-2538-8
  contributor:
    fullname: AM Arvin
– year: 2020
  ident: 703_CR159
  publication-title: Nature
  doi: 10.1038/s41586-020-2575-3
  contributor:
    fullname: M Hoffmann
– year: 2020
  ident: 703_CR97
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2020.117592
  contributor:
    fullname: AA Elfiky
– volume: 45
  start-page: 1463
  year: 2015
  ident: 703_CR29
  publication-title: Eur Respir J
  doi: 10.1183/09031936.00186214
  contributor:
    fullname: S Herold
– ident: 703_CR180
– year: 2020
  ident: 703_CR126
  publication-title: Nat Med
  doi: 10.1038/s41591-020-1038-6
  contributor:
    fullname: AG Laing
– volume: 368
  start-page: 779
  year: 2020
  ident: 703_CR2
  publication-title: Science
  doi: 10.1126/science.abb7498
  contributor:
    fullname: Y Gao
– volume: 99
  start-page: 307
  year: 2020
  ident: 703_CR196
  publication-title: Int J Infect Dis
  doi: 10.1016/j.ijid.2020.06.006
  contributor:
    fullname: E Finzi
– volume: 314
  start-page: 171
  year: 2015
  ident: 703_CR112
  publication-title: Int Rev Cell Mol Biol
  doi: 10.1016/bs.ircmb.2014.09.002
  contributor:
    fullname: EN Tsakiri
– volume: 12
  start-page: 4
  year: 2015
  ident: 703_CR26
  publication-title: Part Fibre Toxicol
  doi: 10.1186/s12989-015-0080-x
  contributor:
    fullname: Y Sun
– volume: 369
  start-page: 256
  year: 2020
  ident: 703_CR146
  publication-title: Science
  doi: 10.1126/science.abb0762
  contributor:
    fullname: AN Akbar
– volume: 46
  start-page: 169
  year: 2020
  ident: 703_CR185
  publication-title: Encephale
  doi: 10.1016/j.encep.2020.05.006
  contributor:
    fullname: M Plaze
– volume: 370
  start-page: 642
  issue: 6517
  year: 2020
  ident: 703_CR100
  publication-title: Science
  doi: 10.1126/science.370.6517.642
  contributor:
    fullname: J Cohen
– year: 2020
  ident: 703_CR31
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc2011400
  contributor:
    fullname: VG Puelles
– volume: 39
  start-page: 209
  year: 2016
  ident: 703_CR189
  publication-title: Drug Saf
  doi: 10.1007/s40264-015-0371-z
  contributor:
    fullname: RI Okonkwo
– volume: 17
  start-page: 1139
  year: 2016
  ident: 703_CR90
  publication-title: Traffic
  doi: 10.1111/tra.12425
  contributor:
    fullname: SR Elkin
– year: 2020
  ident: 703_CR140
  publication-title: Science
  doi: 10.1126/science.abe8499
  contributor:
    fullname: YJ Hou
– year: 2020
  ident: 703_CR114
  publication-title: Nature
  doi: 10.1038/s41586-020-2332-7
  contributor:
    fullname: D Bojkova
– volume: 124
  start-page: 443
  year: 2013
  ident: 703_CR116
  publication-title: Clin Sci (Lond)
  doi: 10.1042/CS20120461
  contributor:
    fullname: DG Passos-Silva
– volume: 369
  start-page: eabc8511
  year: 2020
  ident: 703_CR124
  publication-title: Science
  doi: 10.1126/science.abc8511
  contributor:
    fullname: D Mathew
– volume: 64
  start-page: e00754
  year: 2020
  ident: 703_CR181
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.00754-20
  contributor:
    fullname: M Hoffmann
– year: 2020
  ident: 703_CR68
  publication-title: Science
  doi: 10.1126/science.abc5902
  contributor:
    fullname: PJM Brouwer
– volume: 580
  start-page: 3989
  year: 2006
  ident: 703_CR113
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2006.06.029
  contributor:
    fullname: FL Stratford
– volume: 40
  start-page: BSR20201256
  year: 2020
  ident: 703_CR187
  publication-title: Biosci Rep.
  doi: 10.1042/BSR20201256
  contributor:
    fullname: A Shamsi
– year: 2020
  ident: 703_CR95
  publication-title: Science
  doi: 10.1126/science.abb3405
  contributor:
    fullname: L Zhang
– volume: 395
  start-page: 1417
  year: 2020
  ident: 703_CR120
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30937-5
  contributor:
    fullname: Z Varga
– year: 2020
  ident: 703_CR57
  publication-title: Science
  doi: 10.1126/science.abc6284
  contributor:
    fullname: J Yu
– volume: 38
  start-page: 1073
  issue: 9
  year: 2020
  ident: 703_CR83
  publication-title: Nat Biotechnol.
  doi: 10.1038/s41587-020-0631-z
  contributor:
    fullname: CW Tan
– volume: 93
  start-page: 528
  year: 2008
  ident: 703_CR119
  publication-title: Exp Physiol
  doi: 10.1113/expphysiol.2007.040345
  contributor:
    fullname: N Alenina
– ident: 703_CR166
– year: 2020
  ident: 703_CR135
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2021436
  contributor:
    fullname: The RECOVERY Collaborative Group
– volume: 212
  start-page: 29
  year: 2018
  ident: 703_CR179
  publication-title: Cancer Res
  contributor:
    fullname: M Lindauer
– volume: 25
  start-page: 54
  issue: 1
  year: 2020
  ident: 703_CR41
  publication-title: Eur J Med Res.
  doi: 10.1186/s40001-020-00454-x
  contributor:
    fullname: ZH Wu
– year: 2020
  ident: 703_CR62
  publication-title: Nature
  doi: 10.1038/s41586-020-2608-y
  contributor:
    fullname: N van Doremalen
– volume: 183
  start-page: 996
  issue: 4
  year: 2020
  ident: 703_CR133
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.038
  contributor:
    fullname: C Rydyznski Moderbacher
– volume: 182
  start-page: 812
  year: 2020
  ident: 703_CR141
  publication-title: Cell
  doi: 10.1016/j.cell.2020.06.043
  contributor:
    fullname: B Korber
– year: 2020
  ident: 703_CR60
  publication-title: Nature
  doi: 10.1038/s41586-020-2622-0
  contributor:
    fullname: KS Corbett
– year: 2020
  ident: 703_CR36
  publication-title: Science
  doi: 10.1126/science.abc1669
  contributor:
    fullname: MM Lamers
– volume: 369
  start-page: m1849
  year: 2020
  ident: 703_CR105
  publication-title: BMJ
  doi: 10.1136/bmj.m1849
  contributor:
    fullname: W Tang
– volume: 12
  start-page: e10923
  issue: 10
  year: 2020
  ident: 703_CR44
  publication-title: Cureus
  contributor:
    fullname: S Abdulla
– volume: 368
  start-page: 1274
  year: 2020
  ident: 703_CR78
  publication-title: Science
  doi: 10.1126/science.abc2241
  contributor:
    fullname: Y Wu
– volume: 2
  start-page: e474
  year: 2020
  ident: 703_CR198
  publication-title: Lancet Rheumatol
  doi: 10.1016/S2665-9913(20)30173-9
  contributor:
    fullname: G Guaraldi
– volume: 369
  start-page: 1014
  issue: 6506
  year: 2020
  ident: 703_CR75
  publication-title: Science
  doi: 10.1126/science.abd0831
  contributor:
    fullname: A Baum
– volume: 14
  start-page: 983
  year: 2020
  ident: 703_CR201
  publication-title: Diabetes Metab Syndr
  doi: 10.1016/j.dsx.2020.06.047
  contributor:
    fullname: R Pranata
– year: 2020
  ident: 703_CR129
  publication-title: Cell
  doi: 10.1016/j.cell.2020.04.026
  contributor:
    fullname: D Blanco-Melo
– volume: 55
  start-page: 735
  year: 2012
  ident: 703_CR107
  publication-title: Arch Gerontol Geriatr
  doi: 10.1016/j.archger.2012.05.007
  contributor:
    fullname: A Wyczałkowska-Tomasik
– volume: 102
  start-page: 39
  year: 2020
  ident: 703_CR195
  publication-title: Nitric Oxide
  doi: 10.1016/j.niox.2020.06.002
  contributor:
    fullname: J Wu
– volume: 9
  start-page: 61390
  year: 2020
  ident: 703_CR8
  publication-title: Elife.
  doi: 10.7554/eLife.61390
  contributor:
    fullname: NZ Cuervo
– year: 2020
  ident: 703_CR64
  publication-title: Nature
  doi: 10.1038/s41586-020-2814-7
  contributor:
    fullname: U Sahin
– volume: 182
  start-page: 722
  year: 2020
  ident: 703_CR149
  publication-title: Cell
  doi: 10.1016/j.cell.2020.06.035
  contributor:
    fullname: L Dai
– volume: 13
  start-page: 2309
  year: 2006
  ident: 703_CR106
  publication-title: Curr Med Chem
  doi: 10.2174/092986706777935122
  contributor:
    fullname: R Frlan
– ident: 703_CR170
– volume: 9
  start-page: 852
  year: 2019
  ident: 703_CR182
  publication-title: Front Oncol
  doi: 10.3389/fonc.2019.00852
  contributor:
    fullname: X Chen
– volume: 580
  start-page: 576
  issue: 7805
  year: 2020
  ident: 703_CR55
  publication-title: Nature
  doi: 10.1038/d41586-020-01221-y
  contributor:
    fullname: E Callaway
– volume: 181
  start-page: e19
  issue: 1016–1035
  year: 2020
  ident: 703_CR19
  publication-title: Cell
  contributor:
    fullname: CGK Ziegler
– year: 2020
  ident: 703_CR18
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0868-6
  contributor:
    fullname: W Sungnak
– volume: 118
  start-page: 1313
  year: 2016
  ident: 703_CR117
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.116.307708
  contributor:
    fullname: VB Patel
– volume: 36
  start-page: 101615
  year: 2020
  ident: 703_CR17
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2020.101615
  contributor:
    fullname: E Gkogkou
– year: 2020
  ident: 703_CR53
  publication-title: Science
  doi: 10.1126/science.abb8925
  contributor:
    fullname: JB Moore
– volume: 125
  start-page: 21
  year: 2017
  ident: 703_CR15
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2017.06.005
  contributor:
    fullname: XC Li
– year: 2020
  ident: 703_CR128
  publication-title: Cell Host Microbe.
  doi: 10.1016/j.chom.2020.04.009
  contributor:
    fullname: EJ Giamarellos-Bourboulis
– year: 2020
  ident: 703_CR137
  publication-title: Nature
  doi: 10.1038/s41586-020-2598-9
  contributor:
    fullname: J Braun
– year: 2020
  ident: 703_CR102
  publication-title: Int J Antimicrob Agents
  doi: 10.1016/j.ijantimicag.2020.105938
  contributor:
    fullname: CA Devaux
– year: 2020
  ident: 703_CR127
  publication-title: Cell Rep Med
  doi: 10.1016/j.xcrm.2020.100016
  contributor:
    fullname: SR Bonam
– year: 2020
  ident: 703_CR22
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2006923
  contributor:
    fullname: G Mancia
– volume: 21
  start-page: 234
  year: 2017
  ident: 703_CR167
  publication-title: Crit Care
  doi: 10.1186/s13054-017-1823-x
  contributor:
    fullname: A Khan
– year: 2020
  ident: 703_CR69
  publication-title: Nature
  doi: 10.1038/s41586-020-2380-z
  contributor:
    fullname: B Ju
– volume: 487
  start-page: 477
  year: 2012
  ident: 703_CR16
  publication-title: Nature
  doi: 10.1038/nature11228
  contributor:
    fullname: T Hashimoto
– ident: 703_CR165
– year: 2020
  ident: 703_CR65
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2026920
  contributor:
    fullname: C Keech
– year: 2020
  ident: 703_CR61
  publication-title: Nature
  doi: 10.1038/s41586-020-2607-z
  contributor:
    fullname: NB Mercado
– year: 2020
  ident: 703_CR33
  publication-title: Nature
  doi: 10.1038/s41586-020-2196-x
  contributor:
    fullname: R Wölfel
– year: 2020
  ident: 703_CR190
  publication-title: J Cell Physiol.
  doi: 10.1002/jcp.29785
  contributor:
    fullname: B Yousefi
– volume: 369
  start-page: 1261
  year: 2020
  ident: 703_CR157
  publication-title: Science
  doi: 10.1126/science.abc0870
  contributor:
    fullname: KK Chan
– ident: 703_CR176
– year: 2020
  ident: 703_CR77
  publication-title: Science
  doi: 10.1126/science.abe3354
  contributor:
    fullname: MA Tortorici
– volume: 182
  start-page: 744
  issue: 3
  year: 2020
  ident: 703_CR80
  publication-title: Cell
  doi: 10.1016/j.cell.2020.06.011
  contributor:
    fullname: AO Hassan
– volume: 52
  start-page: 68
  year: 2018
  ident: 703_CR109
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2018.04.014
  contributor:
    fullname: CW Keller
– year: 2020
  ident: 703_CR46
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2020.11.005
  contributor:
    fullname: I Kusmartseva
– volume: 436
  start-page: 112
  year: 2005
  ident: 703_CR25
  publication-title: Nature
  doi: 10.1038/nature03712
  contributor:
    fullname: Y Imai
– year: 2020
  ident: 703_CR59
  publication-title: Nature
  doi: 10.1038/s41586-020-2599-8
  contributor:
    fullname: J Yang
– year: 2020
  ident: 703_CR81
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMoa2029849
  contributor:
    fullname: P Chen
– volume: 8674
  start-page: 30229
  issue: 20
  year: 2020
  ident: 703_CR4
  publication-title: Cell
  doi: 10.1016/j.cell.2020.02.052
  contributor:
    fullname: M Hoffmann
– year: 2020
  ident: 703_CR160
  publication-title: JAMA
  doi: 10.1001/jama.2020.17022
  contributor:
    fullname: DC Angus
– year: 2020
  ident: 703_CR122
  publication-title: Am J Hematol
  doi: 10.1002/ajh.25829
  contributor:
    fullname: E Terpos
– year: 2020
  ident: 703_CR132
  publication-title: Science
  doi: 10.1126/science.abd4570
  contributor:
    fullname: Q Zhang
– volume: 16
  start-page: e1008536
  year: 2020
  ident: 703_CR20
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1008536
  contributor:
    fullname: D Tang
– year: 2020
  ident: 703_CR161
  publication-title: JAMA
  doi: 10.1001/jama.2020.17021
  contributor:
    fullname: BM Tomazini
– volume: 182
  start-page: 73
  issue: 1
  year: 2020
  ident: 703_CR74
  publication-title: Cell
  doi: 10.1016/j.cell.2020.05.025
  contributor:
    fullname: Y Cao
– volume: 9
  start-page: E659
  year: 2020
  ident: 703_CR194
  publication-title: Antioxidants (Basel)
  doi: 10.3390/antiox9080659
  contributor:
    fullname: P Mendonca
– volume: 183
  start-page: 16
  issue: 1
  year: 2020
  ident: 703_CR52
  publication-title: Cell
  doi: 10.1016/j.cell.2020.08.028
  contributor:
    fullname: C Iadecola
– ident: 703_CR171
– volume: 182
  start-page: 1284
  issue: 5
  year: 2020
  ident: 703_CR142
  publication-title: Cell
  doi: 10.1016/j.cell.2020.07.012
  contributor:
    fullname: Q Li
– volume: 55
  start-page: 105944
  issue: 4
  year: 2020
  ident: 703_CR193
  publication-title: Int J Antimicrob Agents
  doi: 10.1016/j.ijantimicag.2020.105944
  contributor:
    fullname: SA Baron
– volume: 16
  start-page: 139
  year: 2000
  ident: 703_CR178
  publication-title: Drugs Aging
  doi: 10.2165/00002512-200016020-00005
  contributor:
    fullname: LJ Scott
– volume: 368
  start-page: 356
  year: 2020
  ident: 703_CR54
  publication-title: Science
  doi: 10.1126/science.368.6489.356
  contributor:
    fullname: M Wadman
– year: 2020
  ident: 703_CR5
  publication-title: Nature
  doi: 10.1038/s41586-020-2180-5
  contributor:
    fullname: J Lan
– volume: 368
  start-page: m1252
  year: 2020
  ident: 703_CR3
  publication-title: BMJ
  doi: 10.1136/bmj.m1252
  contributor:
    fullname: E Mahase
– volume: 39
  start-page: e106057
  issue: 21
  year: 2020
  ident: 703_CR93
  publication-title: EMBO J.
  doi: 10.15252/embj.2020106057
  contributor:
    fullname: S Wang
– year: 2020
  ident: 703_CR7
  publication-title: BioRxiv.
  doi: 10.1101/2020.06.07.137802
  contributor:
    fullname: L Cantuti-Castelvetri
– volume: 44
  start-page: 3500
  year: 2014
  ident: 703_CR111
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201445272
  contributor:
    fullname: D Zanker
– volume: 74
  start-page: 405
  year: 2010
  ident: 703_CR12
  publication-title: Circ J
  doi: 10.1253/circj.CJ-10-0045
  contributor:
    fullname: Y Imai
– year: 2020
  ident: 703_CR71
  publication-title: Science
  doi: 10.1126/science.abc7520
  contributor:
    fullname: TF Rogers
– volume: 26
  start-page: e73
  year: 2020
  ident: 703_CR175
  publication-title: Inflamm Bowel Dis
  doi: 10.1093/ibd/izaa114
  contributor:
    fullname: A Tursi
– volume: 117
  start-page: 7001
  year: 2020
  ident: 703_CR89
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.2002589117
  contributor:
    fullname: S Matsuyama
– year: 2020
  ident: 703_CR144
  publication-title: Nature
  doi: 10.1038/s41586-020-2700-3
  contributor:
    fullname: T Takahashi
– ident: 703_CR177
  doi: 10.21203/rs.3.rs-48659/v1
– year: 2020
  ident: 703_CR153
  publication-title: Science
  doi: 10.1126/science.abc6952
  contributor:
    fullname: X Chi
– ident: 703_CR164
– year: 2020
  ident: 703_CR87
  publication-title: Basic Clin Pharmacol Toxicol.
  doi: 10.1111/bcpt.13533
  contributor:
    fullname: P Breining
– volume: 584
  start-page: 457
  year: 2020
  ident: 703_CR136
  publication-title: Nature
  doi: 10.1038/s41586-020-2550-z
  contributor:
    fullname: N Le Bert
– volume: 9
  start-page: 469
  year: 2020
  ident: 703_CR35
  publication-title: Emerg Microbes Infect
  doi: 10.1080/22221751.2020.1732837
  contributor:
    fullname: W Chen
– year: 2020
  ident: 703_CR172
  publication-title: bioRxiv
  doi: 10.1101/2020.05.12.091082
  contributor:
    fullname: Z Ghazizadeh
– year: 2020
  ident: 703_CR99
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2007016
  contributor:
    fullname: J Grein
– year: 2020
  ident: 703_CR139
  publication-title: Nature
  doi: 10.1038/s41586-020-2895-3
  contributor:
    fullname: JA Plante
– ident: 703_CR9
  doi: 10.1016/j.bbrc.2020.09.042
– volume: 87
  start-page: 89
  year: 2014
  ident: 703_CR101
  publication-title: Eur J Med Chem
  doi: 10.1016/j.ejmech.2014.09.051
  contributor:
    fullname: R Kaur
– volume: 182
  start-page: 1271
  year: 2020
  ident: 703_CR151
  publication-title: Cell
  doi: 10.1016/j.cell.2020.07.024
  contributor:
    fullname: NN Zhang
– year: 2020
  ident: 703_CR174
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2020.05.065
  contributor:
    fullname: N Khan
– year: 2019
  ident: 703_CR108
  publication-title: Eur J Prev Cardiol
  doi: 10.1177/2047487319893042
  contributor:
    fullname: A Mareti
– year: 2020
  ident: 703_CR34
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2607.200839
  contributor:
    fullname: L Chang
– volume: 2
  start-page: e0284
  issue: 11
  year: 2020
  ident: 703_CR86
  publication-title: Crit Care Explor.
  doi: 10.1097/CCE.0000000000000284
  contributor:
    fullname: H Hofmann-Winkler
– volume: 76
  start-page: e13
  year: 2020
  ident: 703_CR202
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.120.15572
  contributor:
    fullname: X Guo
– volume: 40
  start-page: 580
  issue: 8
  year: 2013
  ident: 703_CR47
  publication-title: Clin Exp Pharmacol Physiol
  doi: 10.1111/1440-1681.12137
  contributor:
    fullname: C Sumners
– volume: 33
  start-page: 1
  year: 2019
  ident: 703_CR103
  publication-title: Cardiovasc Drugs Ther
  doi: 10.1007/s10557-018-06847-9
  contributor:
    fullname: M Blignaut
– volume: S0168–9525
  start-page: 30203
  issue: 20
  year: 2020
  ident: 703_CR143
  publication-title: Trends Genet
  contributor:
    fullname: P Brest
– year: 2020
  ident: 703_CR24
  publication-title: Nature
  doi: 10.1038/s41586-020-2312-y
  contributor:
    fullname: L Bao
– year: 2020
  ident: 703_CR38
  publication-title: J Gastroenterol Hepatol
  doi: 10.1111/jgh.15047
  contributor:
    fullname: SH Wong
– year: 2020
  ident: 703_CR134
  publication-title: Nature
  doi: 10.1038/s41586-020-2355-0
  contributor:
    fullname: X Zhang
– year: 2020
  ident: 703_CR45
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2020.11.006
  contributor:
    fullname: KC Coate
– year: 2020
  ident: 703_CR130
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0944-y
  contributor:
    fullname: AJ Wilk
– year: 2020
  ident: 703_CR203
  publication-title: J Physiol Pharmacol
  doi: 10.26402/jpp.2020.2.01
  contributor:
    fullname: D Dworakowska
– year: 2020
  ident: 703_CR50
  publication-title: EMBO J.
  doi: 10.15252/embj.2020106230
  contributor:
    fullname: A Ramani
– volume: 8
  start-page: e001089
  issue: 2
  year: 2020
  ident: 703_CR199
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-001089
  contributor:
    fullname: V Montesarchio
– volume: S1931–3128
  start-page: 30302
  issue: 20
  year: 2020
  ident: 703_CR40
  publication-title: Cell Host Microbe
  contributor:
    fullname: SH Sun
– volume: 302
  start-page: 193
  year: 2009
  ident: 703_CR11
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2008.09.020
  contributor:
    fullname: SM Bindom
– volume: S1665–2681
  start-page: 30188
  issue: 20
  year: 2020
  ident: 703_CR42
  publication-title: Ann Hepatol
  contributor:
    fullname: A Sharma
– year: 2020
  ident: 703_CR21
  publication-title: Drug Discov Ther
  doi: 10.5582/ddt.2020.01017
  contributor:
    fullname: GH Marin
– year: 2020
  ident: 703_CR56
  publication-title: Science
  doi: 10.1126/science.abc1932
  contributor:
    fullname: Q Gao
– year: 2020
  ident: 703_CR84
  publication-title: Cell
  doi: 10.1016/j.cell.2020.04.004
  contributor:
    fullname: V Monteil
– volume: 585
  start-page: 16
  year: 2020
  ident: 703_CR145
  publication-title: Nature
  doi: 10.1038/d41586-020-02483-2
  contributor:
    fullname: S Mallapaty
– ident: 703_CR163
– volume: 3
  start-page: e2013136
  year: 2020
  ident: 703_CR191
  publication-title: JAMA Netw Open
  doi: 10.1001/jamanetworkopen.2020.13136
  contributor:
    fullname: SG Deftereos
– volume: 370
  start-page: 1110
  issue: 6520
  year: 2020
  ident: 703_CR76
  publication-title: Science
  doi: 10.1126/science.abe2402
  contributor:
    fullname: A Baum
– year: 2020
  ident: 703_CR123
  publication-title: Nat Med
  doi: 10.1038/s41591-020-1021-2
  contributor:
    fullname: V Ramlall
– volume: 87
  start-page: 8017
  year: 2013
  ident: 703_CR85
  publication-title: J Virol
  doi: 10.1128/JVI.00998-13
  contributor:
    fullname: AO Adedeji
– volume: 5
  start-page: 256
  issue: 1
  year: 2020
  ident: 703_CR43
  publication-title: Signal Transduct Target Ther.
  doi: 10.1038/s41392-020-00373-7
  contributor:
    fullname: P Zhong
– year: 2020
  ident: 703_CR72
  publication-title: Nature
  doi: 10.1038/s41586-020-2381-y
  contributor:
    fullname: R Shi
– volume: 144
  start-page: 111639
  year: 2020
  ident: 703_CR184
  publication-title: Food Chem Toxicol
  doi: 10.1016/j.fct.2020.111639
  contributor:
    fullname: D Javorac
– volume: 136
  start-page: 95
  year: 2004
  ident: 703_CR27
  publication-title: Clin Exp Immunol
  doi: 10.1111/j.1365-2249.2004.02415.x
  contributor:
    fullname: CK Wong
– year: 2020
  ident: 703_CR96
  publication-title: Nature
  doi: 10.1038/s41586-020-2368-8
  contributor:
    fullname: HS Hillen
– year: 2020
  ident: 703_CR73
  publication-title: Science
  doi: 10.1126/science.abd0827
  contributor:
    fullname: J Hansen
– year: 2020
  ident: 703_CR152
  publication-title: Nat Med
  doi: 10.1038/s41591-020-1048-4
  contributor:
    fullname: KM Edwards
– year: 2020
  ident: 703_CR39
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0912-6
  contributor:
    fullname: J Zhou
– year: 2020
  ident: 703_CR131
  publication-title: Science
  doi: 10.1126/science.abd4585
  contributor:
    fullname: P Bastard
– volume: 17
  start-page: 3
  issue: 2
  year: 2015
  ident: 703_CR48
  publication-title: Curr Hypertens Rep
  doi: 10.1007/s11906-014-0512-2
  contributor:
    fullname: DM Bennion
– volume: 369
  start-page: 731
  year: 2020
  ident: 703_CR154
  publication-title: Science
  doi: 10.1126/science.abc7424
  contributor:
    fullname: Z Anna
– volume: 3
  start-page: 5
  year: 2004
  ident: 703_CR188
  publication-title: Ann Hepatol
  doi: 10.1016/S1665-2681(19)32118-0
  contributor:
    fullname: ML Shiffman
– volume: 369
  start-page: 238
  issue: 6501
  year: 2020
  ident: 703_CR138
  publication-title: Science
  doi: 10.1126/science.369.6501.238
  contributor:
    fullname: K Kupferschmidt
– volume: 56
  start-page: 105949
  year: 2020
  ident: 703_CR192
  publication-title: Int J Antimicrob Agents
  doi: 10.1016/j.ijantimicag.2020.105949
  contributor:
    fullname: P Gautret
– ident: 703_CR168
– volume: 369
  start-page: m2263
  year: 2020
  ident: 703_CR104
  publication-title: BMJ
  doi: 10.1136/bmj.m2263
  contributor:
    fullname: I Torjesen
– volume: 81
  start-page: e1
  year: 2020
  ident: 703_CR183
  publication-title: J Infect
  doi: 10.1016/j.jinf.2020.03.002
  contributor:
    fullname: L Deng
– volume: 9
  start-page: 680
  issue: 1
  year: 2020
  ident: 703_CR82
  publication-title: Emerg Microbes Infect
  doi: 10.1080/22221751.2020.1743767
  contributor:
    fullname: J Jianhui Nie
– volume: 584
  start-page: 443
  year: 2020
  ident: 703_CR79
  publication-title: Nature
  doi: 10.1038/s41586-020-2548-6
  contributor:
    fullname: SJ Zost
– year: 2020
  ident: 703_CR6
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2020.04.022
  contributor:
    fullname: M Hoffmann
– ident: 703_CR186
  doi: 10.1002/14651858.CD000284.pub3
– volume: 383
  start-page: 1056
  issue: 10
  year: 2020
  ident: 703_CR148
  publication-title: N Engl J Med
  contributor:
    fullname: E Terpos
– volume: 17
  start-page: 3
  year: 2015
  ident: 703_CR118
  publication-title: Curr Hypertens Rep
  doi: 10.1007/s11906-014-0512-2
  contributor:
    fullname: DM Bennion
– volume: 182
  start-page: 713
  year: 2020
  ident: 703_CR58
  publication-title: Cell
  doi: 10.1016/j.cell.2020.06.008
  contributor:
    fullname: H Wang
– volume: 275
  start-page: 33238
  issue: 43
  year: 2000
  ident: 703_CR14
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M002615200
  contributor:
    fullname: SR Tipnis
– volume: 87
  start-page: E1
  issue: 5
  year: 2000
  ident: 703_CR13
  publication-title: Circ Res
  doi: 10.1161/01.RES.87.5.e1
  contributor:
    fullname: M Donoghue
– year: 2020
  ident: 703_CR147
  publication-title: Nat Med
  doi: 10.1038/s41591-020-1088-9
  contributor:
    fullname: STH Liu
– year: 2020
  ident: 703_CR155
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0998-x
  contributor:
    fullname: SJ Zost
SSID ssj0015987
Score 2.6401312
SecondaryResourceType review_article
Snippet Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments...
Abstract Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of...
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational...
BACKGROUNDGaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational...
Abstract Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of...
SourceID doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 9
SubjectTerms ACE2
Acute respiratory distress syndrome
Adaptive immunity
Adult respiratory distress syndrome
Age
Angiotensin II
Angiotensin-converting enzyme 2
Antigen presentation
Antigens
ARDS
Complications
Complications and side effects
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - drug therapy
COVID-19 - physiopathology
COVID-19 - virology
Cycle ratio
Cytokine storm
Cytokines
Disease transmission
Gastrointestinal system
Gastrointestinal tract
Humans
Immune response
Immune system
Infection
Infections
Inflammation
Kidneys
Life Cycle Stages
Life cycles
Organotropism
Proto-Oncogene Mas
Review
SARS-CoV-2
SARS-CoV-2 - isolation & purification
SARS-CoV-2 - physiology
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Storm damage
Tissues
TMPRSS2
Viral diseases
Viral infections
Virus diseases
Viruses
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nb9UwDI_QJBAXBOOrbKAgIXFg0Zqk-ejx8WDakAYSY9NuUZqm2pNQi_a6w8Y_j522T6_iwIVrE7dJ7NR2Yv9MyDvufZV7RAAQpmRgEUfmMVem8U2MQsRapxvd06_6-Lz4cqkut0p9YUzYAA88LNyhDbExdTQlqKKikdH7KHRT2Urlja3NkObL1eRMjfcHClzpKUXG6sM1aDVRMnSVEN9GMjVTQwmt_-9_8pZSmgdMbmmgo8fk0Wg60sUw5CfkXmx3yf2hmOTtLnlwOl6TPyW_T9o1Ot1r2nf0bPH9jC27Cyboz1UTabgF6gOKpYi7dK6R6A-ob2t6PR4Nru5iTTcx6PCaK9_TIWicLr9dnHxivKRTUiWdhaU_I-dHn38sj9lYZYEFpWXPVEiFQ63ljS2i5xEB5gO4SYW0pgyYK2sEqrAoRYUFEGIhY154zcG95WUln5OdtmvjS0JLrSqta2C2rIscuguubcNNXWrjdR0y8mFadPdrANNwyQmx2g0scsAil1jkVEY-Il82PREIOz0A8XCjeLh_iUdG3iNXHW5XYF3wY9YBDBiBr9xCK6mBOofP7c96wjYL8-ZJLty4zddOILQR-JyCZ-TtphkpMXStjd1N6mOKEszOPCMvBjHaTElKsFZh2hkxMwGbzXne0q6uEgi4sVhOUb76H4u0Rx4KDNXJOeNin-z01zfxNdhaffUmbas_XY4lEg
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDI_GEIgXBANGYaAgIfHAomuSNkmf0HEw3ZAGEmPTvUVpm7KTUDvuuofBP4-dfrAKidcmaZPaju3E9o-Q19y5PHZYAUDojIFF7JnDXJnKVd4L4UsVbnRPPqvlWfJpla52yHLIhcGwymFPDBt12RR4Rj4TWEUGzHvBZy7HU4Cinb27_MkQPwrvWXswjVvkNhdgVgBn69XoeoHODlB5iGMN9qSOh_QZo2Zb0HgiY-hGYe0bydKJigqV_P_dr28orGkw5Q3tdPSA3O_NSjrv-OAh2fH1HrnTAU1e75G7J_0V-iPy-7jeokO-pW1DT-dfT9miOWeC_lhXnhbXMPqQIkxxE848wvhD6uqSbvpjw_UvX9IxPh1ec-Fa2gWU08WX8-MPjGd0SLikk5D1x-Ts6OO3xZL1CAysSJVsWVoEUFFjeGUS77jH4vMFuFCJNDorMI9WC1RvXoocwRF8In2cOMXB9eVZLp-Q3bqp_VNCM5XmSpXACLJMYuguuDIV12WmtFNlEZG3w0-3l12hDRscFKNsRyILJLKBRDaNyHuky9gTi2SHB83mu-1lzprCV7r0OgMrJqmkd84LVeUmT-PKlNpE5A1S1aIoI0O5PiMBJoxFsexcpVLB6Bg-dzDpCSJYTJsHvrD9FrC1fxk2Iq_GZhyJYW21b65CH51kYJLGEdnv2GhckpRgycKyI6InDDZZ87SlXl-EAuHaINSifPb_aT0n9wTKQ8wZFwdkt91c-RdgYbX5yyA8fwC5XSDF
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfGENNeEIyvwEBGQuKBGeKP-OMBoVKYNqSCxOi0N8tJHFZpSra2kyj88_icpFvEnnitfWmT-13vLr67H0KvqHN56mACAFOGhIjYEwe9MpWrvGfMlzKe6E6-yoOp-HKSnWygnu6oe4CLG1M74JOazs_e_rpYfQgG_z4avJbvFsFnMUMgEYLpNZxkt9BtJrgAxE_E1alCZiJhHrBZh6hSpX0TzY3X2EZbnIdgwsTo88pnxdH-__6BX_Ngw-rKa-5q_x6628WZeNQC4z7a8PUOutMyT6520NakO1N_gP4c1gvI0Bd42eCj0fcjMm6OCcNns8rjYhWk9zDwFjfxJUiU38OuLvG8e484--1LvC5YD5c5dUvcVpjj8bfjw0-EGtx3YOJBDftDNN3__GN8QDpKBlJkki9JVkSWUa1ppYV31MM0-iLkVIJrZQporFUM_J3nLAe2BC-4T4WTNOTC1OT8Edqsm9o_QdjILJeyDMjgpUjDdkalrqgqjVROlkWC3vQP3Z63kzdszFi0tK22bNCWjdqyWYI-gl7WO2Fqdvygmf-0nRFaXfhKlV6ZENaIinvnPJNVrvMsrXSpdIJeg1YtoC2ornBdi0L4wTAly45kxmWQTsPX7Q52Bpsshss9LmwPactgDlJIUBlN0Mv1MkhCnVvtm8u4RwkTYtQ0QY9bGK1vqUdjgtQAYIN7Hq7Us9M4MVxp4F7kT_9b8hnaZmA1KSWU7aLN5fzSPw_R2DJ_EU3sL6lOLYc
  priority: 102
  providerName: Scholars Portal
Title Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
URI https://www.ncbi.nlm.nih.gov/pubmed/33435929
https://www.proquest.com/docview/2478728721/abstract/
https://search.proquest.com/docview/2477496440
https://pubmed.ncbi.nlm.nih.gov/PMC7801873
https://doaj.org/article/8cef7de791814f3eaae26fb8b50f8d78
Volume 28
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe2IRAvCAaMwKiMhMQD85rYiT8eu7KyIXVMG5v6ZjmOwyptydR2D4N_nrOTlEW88ZJIsS9Nene5O_vudwh9TIzJY-MRAKhQBDxiR4yvlSlN6RylruBhR3d6wo8u0m-zbLaBsq4WJiTt23y-X13f7Ffzq5BbeXtjh12e2PB0OhbSt5Jjw020KRjrQvR26yBToSueb1kNrqOIu0oZyYdLMG5UER8xeZgbRnzfGsbAY1DBxfxrmAJ-_79f6Qdmqp9C-cAmTZ6jZ60ziUfNQ79AG67aRo-b9pL32-jJtN04f4l-H1dLH4Yv8arG56OzczKuLwnF1_PSYXsP1HvYNyeuw0pHoN_Dpirwol0snP9yBV5npcNtrswKN2nkePz98vgLSRTuyixxL1H9FbqYHP4YH5G27wKxGWcrktnQSlTKpJSpM4nzkPMWAqeUSaGsr54V1Bs1x2juWyK4lLk4NTyBgDdROXuNtqq6cm8QVjzLOS-A_axIY5hOEy7LRBSKC8MLG6HP3Z-ubxt4DR3CEsl1wy0N3NKBWzqL0IHny3qmh8YOF-rFT90KiJbWlaJwQoHvkpbMGeMoL3OZZ3EpCyEj9MlzVXsFBtZZ09YhwAN7KCw94hnjQB3Dz-32ZoLi2f5wJxe6Vfylph7sCKJQmkTow3rYU_pktsrVd2GOSBU4onGEdhoxWr9SJ40REj0B671zfwS0JMCCt1rx9r8p36Gn1GtNnJCE7qKt1eLOvQeXa5UPQNFmAo5y8nWAHh0cnpyewTmI1yAsY8BxmspBUMU_lrws0A
link.rule.ids 230,315,733,786,790,870,891,2115,12083,12792,21416,24346,27957,27958,31754,31755,33408,33409,33779,33780,38551,43345,43635,43840,43930,53827,53829
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdgiI8XBINBYICRkHhg1mI7sZ0nVApTC-uQ2If6ZjmJwyqhZDTdw-Cf585JyyIkXmM7sXN3vjv77n6EvOHO5bHDCgBCZwwsYs8c5spUrvJeCF-qcKM7O1KT0-TzPJ33B25tH1a53hPDRl02BZ6R7wusIgPmveDvL34yRI3C29UeQuMmuZVImWBIn55vHC7Q1AEgD9GrwYrU8Tppxqj9FvScyBg6T1jxRrJ0oJhC_f5_d-lramoYQnlNJx08IPd7Y5KOOuo_JDd8vU1ud_CSV9vkzqy_OH9Efk_rFt3wlq4aejz6dszGzRkT9Mei8rS4gtF7FMGJm3DSEcbvUVeXdNkfFi5--ZJuotLhNeduRbswcjr-ejb9yHhG12mWdBCo_picHnw6GU9Yj7vAilTJFUuLACVqDK9M4h33WHK-AMcpkUZnBWbPaoFKzUuRIySCT6SPE6c4OLw8y-UO2aqb2j8lNFNprlQJ5JdlEkN3wZWpuC4zpZ0qi4i8W_90e9GV17DBLTHKdiSyQCIbSGTTiHxAumx6Ymns8KBZfre9pFlT-EqXXmdguySV9M55oarc5GlcmVKbiLxFqloUYCBd4fo8BJgwlsKyI5VKBaNj-NzuoCcIXjFsXvOF7QW_tX_ZNCKvN804EoPZat9chj46ycAQjSPypGOjzZKAi2UKy46IHjDYYM3DlnpxHsqCa4MAi_LZ_6f1itydnMwO7eH06Mtzck-gbMSccbFLtlbLS_8CbKxV_jII0h-LAB_4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgiGkvfIyvwAAjIfHA3CZ24o_H0lGtQMfE2DTtxXIcZ6vYkqpNHzb-eWwnKQ287bW-S2r5Z99dfPc7AN5HSqWhcgwAmAlkPWKDlKuVyVVuDMYmo_5Gd3JA94_jL6fJ6VqrL5-0r9Npr7i86hXTC59bObvS_TZPrH84GTLuWsmR_izL-3fBPbtnsWgD9eYCIRG-N55rXG0dSBa29TKc9hfWxGGBXNzkyG4Ict1rCLF-g_CO5l_z5Fn8_z-r14xVN5FyzTKNHoKzdk51Qsqv3rJKe_rmH7rHW036EXjQ-KtwUIs8BndMsQ3u1x0sr7fB5qS5m38Cfo-LhYv0F7Aq4dHgxxEalicIw8tpbqC-ttq70PU_Lv3HFK-_C1WRwXnzPXJ6YzK4Sny3j7lQFawz1eHw-8l4D0UCtpWcsJML_xQcjz7_HO6jprUD0gklFUq071bKeZTz2KjIOFZ7bWOzmHAmtCvQZdjZTUNw6roumJiYMFY0sjF1JFLyDGwUZWFeAChoklKaWYSRLA6tOI4ozyOWCcoUzXQAPrYrKmc1g4f0kQ-nsoaCtFCQHgoyCcAnt-grSce-7X8o5-eyWQ7JtclZZpiw7lGcE6OUwTRPeZqEOc8YD8AHBxnpzgiLC62aUgf7hx3blhzQhFCrHdrX7XQk7d7W3eEWdLI5WxYSOz4lG-jiKADvVsNO0-XLFaZcehkWC-vrhgF4XmN0NaUW6gFgHfR25twdsZj0zOMNBl_eWvMt2DzcG8lv44Ovr8AWdrszjFCEd8BGNV-a19bBq9I3fiv_AYymSnw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Insights+to+SARS-CoV-2+life+cycle%2C+pathophysiology%2C+and+rationalized+treatments+that+target+COVID-19+clinical+complications&rft.jtitle=Journal+of+biomedical+science&rft.au=Trougakos%2C+Ioannis+P.&rft.au=Stamatelopoulos%2C+Kimon&rft.au=Terpos%2C+Evangelos&rft.au=Tsitsilonis%2C+Ourania+E.&rft.date=2021-01-12&rft.pub=BioMed+Central&rft.issn=1021-7770&rft.eissn=1423-0127&rft.volume=28&rft_id=info:doi/10.1186%2Fs12929-020-00703-5&rft_id=info%3Apmid%2F33435929&rft.externalDBID=PMC7801873
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1423-0127&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1423-0127&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1423-0127&client=summon