Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia - Xia, Dan; Lianoglou, Steve; Sandmann, Thomas; Calvert, Meredith; Suh, Jung H.; Thomsen, Elliot; Dugas, Jason; Pizzo, Michelle E.; DeVos, Sarah L.; Earr, Timothy K.; Lin, Chia-Ching; Davis, Sonnet; et al. (Molecular neurodegeneration, 2022)
Keywords: Advertising executives; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Amyloid precursor protein; Amyloidosis - metabolism; Animal models; Animals; Astrogliosis; Biomarkers; Brain - metabolism; Brain research; Cerebrospinal fluid; Cloning; Coding; Disease Models, Animal; Energy metabolism; Enzymes; Gene expression; Genetic aspects; Genetic engineering; Genetically modified organisms; Homologous recombination; Hyperactivity; Imaging systems; Immune response; Instrument industry; Laboratories; Lipid dyshomeostasis; Lipid metabolism; Lipids; Medical research; Medicine, Experimental; Metabolic pathways; Metabolism; Metabolites; Metabolomics; Mice; Mice, Transgenic; Microglia; Microglia - metabolism; Mutation; Neuritic plaques; Neurodegeneration; Neurodegenerative diseases; Neuroimaging; Neuronal-glial interactions; Neurosciences; Pathology; PET imaging; Phagocytic microglia; Phenotypes; Plaque, Amyloid - pathology; Positron emission tomography; Protein engineering; Receptors, GABA - metabolism; Rodents; Senile plaques; Vascular amyloid; β-Amyloid; Canada; Austria; Sweden; Arctic; United States; Sacramento California; Australia; United States--US; Arctic region; Astrogliosis; Neuritic plaques; Neurodegeneration; Vascular amyloid; Phagocytic microglia; Lipid dyshomeostasis