Activation and Repolarization of the Normal Human Heart under Complete Physiological Conditions
Knowledge of normal human cardiac excitation stems from isolated heart or intraoperative mapping studies under nonphysiological conditions. Here, we use a noninvasive imaging modality (electrocardiographic imaging) to study normal activation and repolarization in intact unanesthetized healthy adults...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 16; pp. 6309 - 6314 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
18.04.2006
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Knowledge of normal human cardiac excitation stems from isolated heart or intraoperative mapping studies under nonphysiological conditions. Here, we use a noninvasive imaging modality (electrocardiographic imaging) to study normal activation and repolarization in intact unanesthetized healthy adults under complete physiological conditions. Epicardial potentials, electrograms, and isochrones were noninvasively reconstructed. The normal electrophysiological sequence during activation and repolarization was imaged in seven healthy subjects (four males and three females). Electrocardiographic imaging depicted salient features of normal ventricular activation, including timing and location of the earliest right ventricular (RV) epicardial breakthrough in the anterior paraseptal region, subsequent RV and left ventricular (LV) breakthroughs, apex-to-base activation of posterior LV, and late activation of LV base or RV outflow tract. The repolarization sequence was unaffected by the activation sequence, supporting the hypothesis that in normal hearts, local action potential duration (APD) determines local repolarization time. Mean activation recovery interval (ARI), reflecting local APD, was in the typical human APD range (235 ms). Mean LV apex-to-base ARI dispersion was 42 ms. Average LV ARI exceeded RV ARI by 32 ms. Atrial images showed activation spreading from the sinus node to the rest of the atria, ending at the left atrial appendage. This study provides previously undescribed characterization of human cardiac activation and repolarization under normal physiological conditions. A common sequence of activation was identified, with interindividual differences in specific patterns. The repolarization sequence was determined by local repolarization properties rather than by the activation sequence, and significant dispersion of repolarization was observed between RV and LV and from apex to base. |
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| AbstractList | Knowledge of normal human cardiac excitation stems from isolated heart or intraoperative mapping studies under nonphysiological conditions. Here, we use a noninvasive imaging modality (electrocardiographic imaging) to study normal activation and repolarization in intact unanesthetized healthy adults under complete physiological conditions. Epicardial potentials, electrograms, and isochrones were noninvasively reconstructed. The normal electrophysiological sequence during activation and repolarization was imaged in seven healthy subjects (four males and three females). Electrocardiographic imaging depicted salient features of normal ventricular activation, including timing and location of the earliest right ventricular (RV) epicardial breakthrough in the anterior paraseptal region, subsequent RV and left ventricular (LV) breakthroughs, apex-to-base activation of posterior LV, and late activation of LV base or RV outflow tract. The repolarization sequence was unaffected by the activation sequence, supporting the hypothesis that in normal hearts, local action potential duration (APD) determines local repolarization time. Mean activation recovery interval (ARI), reflecting local APD, was in the typical human APD range (235 ms). Mean LV apex-to-base ARI dispersion was 42 ms. Average LV ARI exceeded RV ARI by 32 ms. Atrial images showed activation spreading from the sinus node to the rest of the atria, ending at the left atrial appendage. This study provides previously undescribed characterization of human cardiac activation and repolarization under normal physiological conditions. A common sequence of activation was identified, with interindividual differences in specific patterns. The repolarization sequence was determined by local repolarization properties rather than by the activation sequence, and significant dispersion of repolarization was observed between RV and LV and from apex to base. Knowledge of normal human cardiac excitation stems from isolated heart or intraoperative mapping studies under nonphysiological conditions. Here, we use a noninvasive imaging modality (electrocardiographic imaging) to study normal activation and repolarization in intact unanesthetized healthy adults under complete physiological conditions. Epicardial potentials, electrograms, and isochrones were noninvasively reconstructed. The normal electrophysiological sequence during activation and repolarization was imaged in seven healthy subjects (four males and three females). Electrocardiographic imaging depicted salient features of normal ventricular activation, including timing and location of the earliest right ventricular (RV) epicardial breakthrough in the anterior paraseptal region, subsequent RV and left ventricular (LV) breakthroughs, apex-to-base activation of posterior LV, and late activation of LV base or RV outflow tract. The repolarization sequence was unaffected by the activation sequence, supporting the hypothesis that in normal hearts, local action potential duration (APD) determines local repolarization time. Mean activation recovery interval (ARI), reflecting local APD, was in the typical human APD range (235 ms). Mean LV apex-to-base ARI dispersion was 42 ms. Average LV ARI exceeded RV ARI by 32 ms. Atrial images showed activation spreading from the sinus node to the rest of the atria, ending at the left atrial appendage. This study provides previously undescribed characterization of human cardiac activation and repolarization under normal physiological conditions. A common sequence of activation was identified, with interindividual differences in specific patterns. The repolarization sequence was determined by local repolarization properties rather than by the activation sequence, and significant dispersion of repolarization was observed between RV and LV and from apex to base.Knowledge of normal human cardiac excitation stems from isolated heart or intraoperative mapping studies under nonphysiological conditions. Here, we use a noninvasive imaging modality (electrocardiographic imaging) to study normal activation and repolarization in intact unanesthetized healthy adults under complete physiological conditions. Epicardial potentials, electrograms, and isochrones were noninvasively reconstructed. The normal electrophysiological sequence during activation and repolarization was imaged in seven healthy subjects (four males and three females). Electrocardiographic imaging depicted salient features of normal ventricular activation, including timing and location of the earliest right ventricular (RV) epicardial breakthrough in the anterior paraseptal region, subsequent RV and left ventricular (LV) breakthroughs, apex-to-base activation of posterior LV, and late activation of LV base or RV outflow tract. The repolarization sequence was unaffected by the activation sequence, supporting the hypothesis that in normal hearts, local action potential duration (APD) determines local repolarization time. Mean activation recovery interval (ARI), reflecting local APD, was in the typical human APD range (235 ms). Mean LV apex-to-base ARI dispersion was 42 ms. Average LV ARI exceeded RV ARI by 32 ms. Atrial images showed activation spreading from the sinus node to the rest of the atria, ending at the left atrial appendage. This study provides previously undescribed characterization of human cardiac activation and repolarization under normal physiological conditions. A common sequence of activation was identified, with interindividual differences in specific patterns. The repolarization sequence was determined by local repolarization properties rather than by the activation sequence, and significant dispersion of repolarization was observed between RV and LV and from apex to base. Knowledge of normal human cardiac excitation stems from isolated heart or intraoperative mapping studies under nonphysiological conditions. Here, we use a noninvasive imaging modality (electrocardiographic imaging) to study normal activation and repolarization in intact unanesthetized healthy adults under complete physiological conditions. Epicardial potentials, electrograms, and isochrones were noninvasively reconstructed. The normal electrophysiological sequence during activation and repolarization was imaged in seven healthy subjects (four males and three females). Electrocardiographic imaging depicted salient features of normal ventricular activation, including timing and location of the earliest right ventricular (RV) epicardial breakthrough in the anterior paraseptal region, subsequent RV and left ventricular (LV) breakthroughs, apex-to-base activation of posterior LV, and late activation of LV base or RV outflow tract. The repolarization sequence was unaffected by the activation sequence, supporting the hypothesis that in normal hearts, local action potential duration (APD) determines local repolarization time. Mean activation recovery interval (ARI), reflecting local APD, was in the typical human APD range (235 ms). Mean LV apex-to-base ARI dispersion was 42 ms. Average LV ARI exceeded RV ARI by 32 ms. Atrial images showed activation spreading from the sinus node to the rest of the atria, ending at the left atrial appendage. This study provides previously undescribed characterization of human cardiac activation and repolarization under normal physiological conditions. A common sequence of activation was identified, with interindividual differences in specific patterns. The repolarization sequence was determined by local repolarization properties rather than by the activation sequence, and significant dispersion of repolarization was observed between RV and LV and from apex to base. [PUBLICATION ABSTRACT] |
| Author | Ghanem, Raja Jia, Ping Ryu, Kyungmoo Ramanathan, Charulatha Rudy, Yoram |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16606830$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0002-9149(64)90070-0 10.1016/S0002-8703(30)90088-9 10.1161/01.RES.3.1.56 10.1161/01.CIR.78.6.1365 10.1016/j.hrthm.2004.12.022 10.1023/A:1021918118380 10.1161/01.CIR.97.15.1496 10.1016/0002-8703(53)90221-X 10.1161/01.CIR.72.6.1372 10.1161/hc3601.094277 10.1161/01.CIR.59.1.161 10.1161/01.CIR.96.3.1012 10.1161/01.CIR.81.1.281 10.1016/0002-8703(60)90409-9 10.1016/S0735-1097(01)01653-9 10.1161/01.CIR.90.6.3076 10.1136/hrt.30.5.630 10.1161/01.CIR.41.6.899 10.1111/j.1542-474X.1999.tb00220.x 10.1114/1.1588655 10.1161/01.CIR.55.2.268 10.1038/nm1011 10.1161/01.RES.52.6.706 10.1161/01.CIR.102.17.2152 10.1016/j.hrthm.2005.08.019 10.1109/TBME.2002.803519 |
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| References | Rudy Y. (e_1_3_3_27_2) 1992; 20 Burgess M. J. (e_1_3_3_19_2) 1979; 236 Rudy Y. (e_1_3_3_17_2) 2000 e_1_3_3_16_2 e_1_3_3_18_2 e_1_3_3_13_2 e_1_3_3_12_2 e_1_3_3_15_2 e_1_3_3_14_2 e_1_3_3_11_2 Zhang X. (e_1_3_3_22_2) 2005; 289 e_1_3_3_30_2 e_1_3_3_10_2 e_1_3_3_31_2 e_1_3_3_6_2 e_1_3_3_5_2 e_1_3_3_8_2 e_1_3_3_7_2 e_1_3_3_28_2 e_1_3_3_9_2 e_1_3_3_29_2 e_1_3_3_24_2 Tikhonov A. N. (e_1_3_3_25_2) 1977 e_1_3_3_23_2 e_1_3_3_26_2 e_1_3_3_2_2 e_1_3_3_20_2 e_1_3_3_1_2 e_1_3_3_4_2 e_1_3_3_3_2 e_1_3_3_21_2 |
| References_xml | – ident: e_1_3_3_2_2 doi: 10.1016/0002-9149(64)90070-0 – ident: e_1_3_3_4_2 doi: 10.1016/S0002-8703(30)90088-9 – ident: e_1_3_3_18_2 doi: 10.1161/01.RES.3.1.56 – ident: e_1_3_3_24_2 doi: 10.1161/01.CIR.78.6.1365 – ident: e_1_3_3_15_2 doi: 10.1016/j.hrthm.2004.12.022 – ident: e_1_3_3_26_2 doi: 10.1023/A:1021918118380 – ident: e_1_3_3_11_2 doi: 10.1161/01.CIR.97.15.1496 – volume: 236 start-page: H391 year: 1979 ident: e_1_3_3_19_2 publication-title: Am. J. Physiol – ident: e_1_3_3_23_2 doi: 10.1016/0002-8703(53)90221-X – ident: e_1_3_3_31_2 doi: 10.1161/01.CIR.72.6.1372 – ident: e_1_3_3_14_2 doi: 10.1161/hc3601.094277 – start-page: 133 volume-title: Heart Physiology and Pathophysiology year: 2000 ident: e_1_3_3_17_2 – volume: 289 start-page: H2724 year: 2005 ident: e_1_3_3_22_2 publication-title: Am. J. Physiol – ident: e_1_3_3_7_2 doi: 10.1161/01.CIR.59.1.161 – volume: 20 start-page: 25 year: 1992 ident: e_1_3_3_27_2 publication-title: Crit. Rev. Biomed. Eng – ident: e_1_3_3_10_2 doi: 10.1161/01.CIR.96.3.1012 – ident: e_1_3_3_30_2 doi: 10.1161/01.CIR.81.1.281 – ident: e_1_3_3_5_2 doi: 10.1016/0002-8703(60)90409-9 – ident: e_1_3_3_13_2 doi: 10.1016/S0735-1097(01)01653-9 – ident: e_1_3_3_20_2 doi: 10.1161/01.CIR.90.6.3076 – ident: e_1_3_3_6_2 doi: 10.1136/hrt.30.5.630 – ident: e_1_3_3_8_2 doi: 10.1161/01.CIR.41.6.899 – ident: e_1_3_3_28_2 doi: 10.1111/j.1542-474X.1999.tb00220.x – ident: e_1_3_3_29_2 doi: 10.1114/1.1588655 – ident: e_1_3_3_3_2 doi: 10.1161/01.CIR.55.2.268 – ident: e_1_3_3_9_2 doi: 10.1038/nm1011 – ident: e_1_3_3_1_2 doi: 10.1161/01.RES.52.6.706 – ident: e_1_3_3_12_2 doi: 10.1161/01.CIR.102.17.2152 – ident: e_1_3_3_16_2 doi: 10.1016/j.hrthm.2005.08.019 – ident: e_1_3_3_21_2 doi: 10.1109/TBME.2002.803519 – volume-title: Solutions of Ill-Posed Problems year: 1977 ident: e_1_3_3_25_2 |
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| SubjectTerms | Adult Adults Atrial Function - physiology Biological Sciences Canines Computerized axial tomography Electrocardiography Electrocardiography - methods Epicardium Female Heart Heart - physiology Humans Imaging Male Mathematical minima Middle Aged Pericardium - physiology Physiology Ventricular Function - physiology Wave reflection |
| Title | Activation and Repolarization of the Normal Human Heart under Complete Physiological Conditions |
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