Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study

• Published in: Journal of translational medicine Vol. 20; no. 1; pp. 216 - 12
• Main Authors: Chen, Xiong, Hong, Xiaosi, Gao, Wenjing, Luo, Shulu, Cai, Jiahao, Liu, Guochang, Huang, Yinong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.05.2022; BioMed Central; BMC
• Subjects: Accelerometers; Age; Behavior; Biobanks; Body mass index; Causal effect; Computer use; Control; Coronaviruses; COVID-19; COVID-19 - epidemiology; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Disease transmission; Epidemics; Exercise; Genome-Wide Association Study; Genomes; Health aspects; Homeostasis; Hospitalization; Humans; Insulin; Insulin resistance; Laboratories; Leisure; Leisure Activities; Leisure sedentary behavior (LSB); Mendelian randomization (MR); Mendelian Randomization Analysis; Metabolism; Mortality; Obesity; Pandemics; Phenotypes; Physical activity; Physical activity (PA); Public health; Risk factors; Sedentary Behavior; Sensitivity analysis; Severe acute respiratory syndrome coronavirus 2; Smoking; Social interactions; China; United Kingdom > UK; COVID-19; Causal effect; Leisure sedentary behavior (LSB); Mendelian randomization (MR); Physical activity (PA)

The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation has greatly decreased opportunities for physical activity (PA) and increased opportunities for leisure sedentary behaviors (LSB). Given that both PA an...