IRF4 and STAT3 activities are associated with the imbalanced differentiation of T-cells in responses to inhalable particulate matters

• Published in: Respiratory research Vol. 21; no. 1; pp. 123 - 13
• Main Authors: Wu, Jinzhun, Ge, Dandan, Zhong, Taoling, Chen, Zuojia, Zhou, Ying, Hou, Lingyun, Lin, Xiaoliang, Hong, Jiaxu, Liu, Kuai, Qi, Hui, Wang, Chaoying, Zhou, Yulin, Li, Cheng, Wu, Chuan, Wu, Shuiping, Liu, Zuguo, Li, Qiyuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.05.2020; BioMed Central; BMC
• Subjects: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Air pollution; Allergic respiratory disease; Animal models; Animals; Asthma; Carbon; Cell culture; Cell differentiation; Cell Differentiation - drug effects; Cell Differentiation - physiology; Cell lines; China - epidemiology; Chronic obstructive pulmonary disease; Cytokines; Differentiation (biology); Disease; Exposure; Female; Flow cytometry; Gene expression; Gene expression profiling; Genetic aspects; Health aspects; Health care; Helper cells; Humans; Imbalanced T-cell differentiation; Immunogenicity; Inflammation; Interferon regulatory factor 4; Interferon Regulatory Factors - biosynthesis; Interferon Regulatory Factors - genetics; Laboratory animals; Leukocytes (mononuclear); Lymphocytes T; Male; Mice; Mice, Inbred BALB C; Middle Aged; Outdoor air quality; Particulate emissions; Particulate matter; Particulate Matter - administration & dosage; Particulate Matter - adverse effects; Particulate matters; Peripheral blood mononuclear cells; Pollutants; Regulators; Respiratory system; Respiratory tract; Stat3 protein; STAT3 Transcription Factor - biosynthesis; STAT3 Transcription Factor - genetics; T cells; T-Lymphocytes - drug effects; T-Lymphocytes - metabolism; Th17 Cells - drug effects; Th17 Cells - metabolism; Transcription factor; Transcription factors; Young Adult; China; Beijing China; Particulate matters; Allergic respiratory disease; Transcription factor; Gene expression profiling; Imbalanced T-cell differentiation

Particulate Matter (PM) is known to cause inflammatory responses in human. Although prior studies verified the immunogenicity of PM in cell lines and animal models, the effectors of PM exposure in the respiratory system and the regulators of the immunogenicity of PM is not fully elucidated. To ident...