Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1

• Published in: Journal of neuroinflammation Vol. 20; no. 1; p. 39
• Main Authors: Huang, Chunling, Sun, Lulu, Xiao, Chenyang, You, Wenjun, Sun, Li, Wang, Siye, Zhang, Zhijun, Liu, Su
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.02.2023; BioMed Central; BMC
• Subjects: Analysis; Animals; Apoptosis; Astrocyte; Astrocytes; Astrocytes - metabolism; Brain; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - genetics; Brain Injuries, Traumatic - metabolism; CCL3 protein; Central nervous system; Cerebral cortex; Chemokines; Circular RNA; Circular RNA METTL9; Cognition disorders; Cognitive ability; CXCL10 protein; Endonucleases; Fluorescence in situ hybridization; Gel electrophoresis; Immunofluorescence; In Situ Hybridization, Fluorescence; Inflammation; Injuries; Laboratory animals; Localization; Mass spectroscopy; Memory; Microinjection; MicroRNAs; Monocyte chemoattractant protein 1; Nervous system; Neurodegenerative diseases; Neuroinflammation; Neuroinflammatory Diseases; Neurological complications; Prevention; Rats; Ribonuclease; Ribonucleic acid; Risk factors; RNA; RNA sequencing; RNA, Circular - genetics; SND1; Traumatic brain injury; Tumor necrosis factor-TNF; Western blotting; China; United States > US; Neuroinflammation; Traumatic brain injury; Astrocyte; Circular RNA METTL9; Chemokines; SND1

Circular RNAs (circRNAs) are highly enriched in the central nervous system and have been implicated in neurodegenerative diseases. However, whether and how circRNAs contribute to the pathological processes induced by traumatic brain injury (TBI) has not been fully elucidated. We conducted a high-thr...