Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors - Wang, Hong-Gang; Bavley, Charlotte C.; Li, Anfei; Jones, Rebecca M.; Hackett, Jonathan E.; Bayleyen, Yared; Lee, Francis S.; Rajadhyaksha, Anjali M.; Pitt, Geoffrey S. (JCI Insight, 2021)
Keywords: Animal Communication; Animals; Autism Spectrum Disorder; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - psychology; Behavior, Animal; Behavior, Animal - physiology; Brain; Brain - pathology; Cells, Cultured; Correlation of Data; Disease Models, Animal; Gene Expression Regulation; Loss of Function Mutation; Medicine; Mice; NAV1.2 Voltage-Gated Sodium Channel; NAV1.2 Voltage-Gated Sodium Channel - genetics; Neurons; Neurons - metabolism; Neuroscience; R; Mouse models; Neuroscience; Ion channels