CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis

• Published in: Molecular cancer Vol. 20; no. 1; pp. 161 - 16
• Main Authors: Li, Shenglong, Liu, Fei, Zheng, Ke, Wang, Wei, Qiu, Enduo, Pei, Yi, Wang, Shuang, Zhang, Jiaming, Zhang, Xiaojing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.12.2021; BioMed Central; BMC
• Subjects: Analysis; Animals; Antimitotic agents; Antineoplastic agents; Apoptosis; Bone Neoplasms - drug therapy; Bone Neoplasms - etiology; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; Cancer therapies; Cell growth; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Chemotherapy; circDOCK1; Cisplatin; Cisplatin - pharmacology; Cisplatin resistance; Cloning; Cytoplasm; Development and progression; Disease Models, Animal; DNA microarrays; Drug Resistance, Neoplasm - genetics; Female; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Health aspects; Humans; IGF1R; Immunoprecipitation; Metastasis; Mice; MicroRNA; MicroRNAs; MicroRNAs - genetics; miR-339-3p; Operating systems; Osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - etiology; Osteosarcoma - metabolism; Osteosarcoma - pathology; rac GTP-Binding Proteins - genetics; Reagents; Receptor, IGF Type 1 - genetics; Receptor, IGF Type 1 - metabolism; RNA Interference; RNA, Circular - genetics; Sarcoma; Signal Transduction; Therapeutic targets; Tumor cell lines; Tumorigenesis; Tumors; Xenograft Model Antitumor Assays; United States > US; China; Japan; Cisplatin resistance; OS; circDOCK1; miR-339-3p; IGF1R

Circular RNAs (circRNAs), a class of noncoding RNAs (ncRNAs), may modulate gene expression by binding to miRNAs. Additionally, recent studies show that circRNAs participate in some pathological processes. However, there is a large gap in the knowledge about circDOCK1 expression and its biological fu...