Association of carbamylated high-density lipoprotein with coronary artery disease in type 2 diabetes mellitus: carbamylated high-density lipoprotein of patients promotes monocyte adhesion

• Published in: Journal of translational medicine Vol. 18; no. 1; pp. 460 - 13
• Main Authors: Chen, Zhongli, Ding, Song, Wang, Yan Ping, Chen, Liang, Mao, Jing Yan, Yang, Ying, Sun, Jia Teng, Yang, Ke
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.12.2020; BioMed Central; BMC
• Subjects: Angiography; Antibodies; Arteriosclerosis; Atherogenesis; Carbamyl-lysine,coronary artery disease; Carbamylation; Cardiovascular disease; Cell activation; Cell adhesion & migration; Cell adhesion molecules; Cell surface; Cholesterol; Complications and side effects; Coronary artery; Coronary Artery Disease - complications; Coronary heart disease; Coronary vessels; Development and progression; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Endothelial Cells; Health aspects; Heart diseases; High density lipoprotein; High density lipoproteins; Humans; Inflammation; Kidney diseases; Laboratories; Lipids; Lipoproteins; Lipoproteins, HDL; Lysine; Medical imaging; Monocyte adhesion; Monocytes; NF-κB protein; Oxidative stress; Physiological aspects; Proteins; Risk factors; Signal transduction; Type 2 diabetes; Type 2 diabetes mellitus; China; United States > US; Carbamylation; Monocyte adhesion; Carbamyl-lysine,coronary artery disease; Type 2 diabetes mellitus; High-density lipoprotein

Increasing evidence showed that carbamylated lipoprotein accelerated atherosclerosis. However, whether such modification of high-density lipoprotein (HDL) particles alters in type 2 diabetes mellitus (T2DM) patients and facilitates vascular complications remains unclear. We aimed to investigate the...