Transcriptomic alterations underlying metaplasia into specific metaplastic components in metaplastic breast carcinoma

• Published in: Breast cancer research : BCR Vol. 25; no. 1; pp. 11 - 17
• Main Authors: Lien, Huang-Chun, Hsu, Chia-Lang, Lu, Yen-Shen, Chen, Tom Wei-Wu, Chen, I.-Chun, Li, Yu-Chia, Huang, Chiun-Sheng, Cheng, Ann-Lii, Lin, Ching-Hung
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.01.2023; BioMed Central; BMC
• Subjects: Analysis; Biological products industry; Breast cancer; Breast carcinoma; Breast Neoplasms - pathology; Cancer; Carcinoma; Carcinoma, Squamous Cell - pathology; Cell adhesion; Endothelial growth factors; Female; Gene expression; Gene Expression Profiling; Genes; Humans; Hypoxia; Invasive carcinoma of no special type; Lymph nodes; Lymphatic system; Macrophages; Matrix-producing component; Mesenchyme; Metaplasia; Metaplasia - genetics; Metaplastic breast carcinoma; Metastases; Metastasis; Pathogenesis; Principal components analysis; Proteomics; Rhabdoid component; Software; Spindle carcinomatous component; Squamous carcinomatous component; Stem cells; Transcriptome; Transcriptomics; Transforming growth factor-b; Transforming growth factors; Variance analysis; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; United States; United States > US; Spindle carcinomatous component; Metaplastic breast carcinoma; Matrix-producing component; Rhabdoid component; Invasive carcinoma of no special type; Gene expression profile; Squamous carcinomatous component

Metaplastic breast carcinoma (MpBC) typically consists of carcinoma of no special type (NST) with various metaplastic components. Although previous transcriptomic and proteomic studies have reported subtype-related heterogeneity, the intracase transcriptomic alterations between metaplastic component...