Apoptosis of endplate chondrocytes in cervical kyphosis is associated with chronic forward flexed neck: an in vivo rat bipedal walking model

• Published in: Journal of orthopaedic surgery and research Vol. 16; no. 1; p. 5
• Main Authors: Lai, Jinliang, Ji, Guanglin, Zhou, Yuqiao, Chen, Jincai, Zhou, Min, Mo, Jianwen, Zheng, Tiansheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.01.2021; BioMed Central; BMC
• Subjects: Animals; Apoptosis; Bipedal rat; Cervical kyphosis; Cervical Vertebrae - cytology; Cervical Vertebrae - diagnostic imaging; Cervical Vertebrae - pathology; Chondrocyte; Chondrocytes; Chondrocytes - pathology; Chondrocytes - physiology; Chronic Disease; Disease; Disease Models, Animal; DNA nucleotidylexotransferase; DNA polymerases; Enzymes; Ethylenediaminetetraacetic acid; Experiments; Forward flexed neck; Kinases; Kyphosis; Kyphosis - diagnostic imaging; Kyphosis - etiology; Kyphosis - pathology; Labeling; Neck; Neck - pathology; Orthopedics; Pathogenesis; Physiological aspects; Rats; Rats, Sprague-Dawley; Spine (cervical); Transmission electron microscopy; Variance analysis; United States > US; Germany; Forward flexed neck; Cervical kyphosis; Chondrocyte; Bipedal rat; Apoptosis

This study was undertaken to establish a rat bipedal walking model of cervical kyphosis (CK) associated with chronic forward flexed neck and assess the effects of chronic forward flexed neck on endplate chondrocytes. Forty-eight 1-month-old Sprague-Dawley rats were randomly divided into 3 groups: fo...