The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis

• Published in: Molecular cancer Vol. 19; no. 1; pp. 44 - 12
• Main Authors: Chen, Mengnuo, Wong, Chun-Ming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.02.2020; BioMed Central; BMC
• Subjects: Adenosine - analogs & derivatives; Adenosine - chemistry; Animals; Biomarkers, Tumor - genetics; Cancer therapies; Carcinogenesis; Cells; Deoxyribonucleic acid; Disease; DNA; DNA methylation; Epi-transcriptome; Epigenetic inheritance; Epigenetics; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Hepatitis; Hepatocellular carcinoma; Histones; Humans; Infections; Liver; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Mammals; Messenger RNA; Methylation; Methyltransferases; Mutation; N6-methyladenosine; Proteins; Review; RNA epigenetics; RNA Processing, Post-Transcriptional; RNA, Neoplasm - chemistry; RNA, Neoplasm - genetics; United States > US; Hepatocellular carcinoma; N6-methyladenosine; RNA epigenetics; Epi-transcriptome

Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcin...