The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis

Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcin...

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Published inMolecular cancer Vol. 19; no. 1; pp. 44 - 12
Main Authors Chen, Mengnuo, Wong, Chun-Ming
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 28.02.2020
BioMed Central
BMC
Subjects
Adenosine - analogs & derivatives
Adenosine - chemistry
Animals
Biomarkers, Tumor - genetics
Cancer therapies
Carcinogenesis
Cells
Deoxyribonucleic acid
Disease
DNA
DNA methylation
Epi-transcriptome
Epigenetic inheritance
Epigenetics
Gene expression
Gene Expression Regulation, Neoplastic
Genes
Hepatitis
Hepatocellular carcinoma
Histones
Humans
Infections
Liver
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Mammals
Messenger RNA
Methylation
Methyltransferases
Mutation
N6-methyladenosine
Proteins
Review
RNA epigenetics
RNA Processing, Post-Transcriptional
RNA, Neoplasm - chemistry
RNA, Neoplasm - genetics
United States > US
Hepatocellular carcinoma
N6-methyladenosine
RNA epigenetics
Epi-transcriptome
Online AccessGet full text

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Abstract Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control gene expression. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in mammalian cells. m6A modification is important for controlling many cellular and biological processes. Deregulation of m6A modification has been recently implicated in human carcinogenesis, including liver cancer. In this review, we summarize the recent findings on m6A regulation and its biological impacts in normal and cancer cells. We will focus on the deregulation of m6A modification and m6A regulators in liver diseases and liver cancers. We will highlight the clinical relevance of m6A deregulation in liver cancer. We will also discuss the potential of exploiting m6A modification for cancer diagnosis and therapeutics.
AbstractList Abstract Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control gene expression. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in mammalian cells. m6A modification is important for controlling many cellular and biological processes. Deregulation of m6A modification has been recently implicated in human carcinogenesis, including liver cancer. In this review, we summarize the recent findings on m6A regulation and its biological impacts in normal and cancer cells. We will focus on the deregulation of m6A modification and m6A regulators in liver diseases and liver cancers. We will highlight the clinical relevance of m6A deregulation in liver cancer. We will also discuss the potential of exploiting m6A modification for cancer diagnosis and therapeutics.
Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control gene expression. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in mammalian cells. m6A modification is important for controlling many cellular and biological processes. Deregulation of m6A modification has been recently implicated in human carcinogenesis, including liver cancer. In this review, we summarize the recent findings on m6A regulation and its biological impacts in normal and cancer cells. We will focus on the deregulation of m6A modification and m6A regulators in liver diseases and liver cancers. We will highlight the clinical relevance of m6A deregulation in liver cancer. We will also discuss the potential of exploiting m6A modification for cancer diagnosis and therapeutics.
Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control gene expression. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in mammalian cells. m6A modification is important for controlling many cellular and biological processes. Deregulation of m6A modification has been recently implicated in human carcinogenesis, including liver cancer. In this review, we summarize the recent findings on m6A regulation and its biological impacts in normal and cancer cells. We will focus on the deregulation of m6A modification and m6A regulators in liver diseases and liver cancers. We will highlight the clinical relevance of m6A deregulation in liver cancer. We will also discuss the potential of exploiting m6A modification for cancer diagnosis and therapeutics.Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control gene expression. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in mammalian cells. m6A modification is important for controlling many cellular and biological processes. Deregulation of m6A modification has been recently implicated in human carcinogenesis, including liver cancer. In this review, we summarize the recent findings on m6A regulation and its biological impacts in normal and cancer cells. We will focus on the deregulation of m6A modification and m6A regulators in liver diseases and liver cancers. We will highlight the clinical relevance of m6A deregulation in liver cancer. We will also discuss the potential of exploiting m6A modification for cancer diagnosis and therapeutics.
ArticleNumber 44
Audience Academic
Author Wong, Chun-Ming
Chen, Mengnuo
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  surname: Chen
  fullname: Chen, Mengnuo
– sequence: 2
  givenname: Chun-Ming
  surname: Wong
  fullname: Wong, Chun-Ming
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32111216$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Hepatocellular carcinoma
N6-methyladenosine
RNA epigenetics
Epi-transcriptome
Language English
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Snippet Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms...
Abstract Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular...
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StartPage 44
SubjectTerms Adenosine - analogs & derivatives
Adenosine - chemistry
Animals
Biomarkers, Tumor - genetics
Cancer therapies
Carcinogenesis
Cells
Deoxyribonucleic acid
Disease
DNA
DNA methylation
Epi-transcriptome
Epigenetic inheritance
Epigenetics
Gene expression
Gene Expression Regulation, Neoplastic
Genes
Hepatitis
Hepatocellular carcinoma
Histones
Humans
Infections
Liver
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Mammals
Messenger RNA
Methylation
Methyltransferases
Mutation
N6-methyladenosine
Proteins
Review
RNA epigenetics
RNA Processing, Post-Transcriptional
RNA, Neoplasm - chemistry
RNA, Neoplasm - genetics
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Title The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
URI https://www.ncbi.nlm.nih.gov/pubmed/32111216
https://www.proquest.com/docview/2379153001
https://www.proquest.com/docview/2369406239
https://pubmed.ncbi.nlm.nih.gov/PMC7047367
https://doaj.org/article/5067219a16e448f18e29877db3122df7
Volume 19
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