Identification of miRNA-mRNA network and immune-related gene signatures in IgA nephropathy by integrated bioinformatics analysis

• Published in: BMC nephrology Vol. 22; no. 1; p. 392
• Main Authors: Wei, Shi-Yao, Guo, Shuang, Feng, Bei, Ning, Shang-Wei, Du, Xuan-Yi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.11.2021; BioMed Central; BMC
• Subjects: Bioinformatics; Biomarkers; Biopsy; CD4 antigen; CIBERSORT; Computational Biology; Correlation analysis; Datasets; Development and progression; Diagnosis; Disease; EGR-1 protein; Gene expression; Genetic aspects; Genomes; Genomics; Glomerulonephritis; Glomerulonephritis, IGA - genetics; Glomerulonephritis, IGA - immunology; Health aspects; Hub genes; Humans; Identification and classification; IgA glomerulonephritis; IgA nephropathy; Immune cells; Immunoglobulin A; Immunoregulation; Immunotherapy; Leukocytes; Lymphocytes T; Macrophages; Messenger RNA; Methods; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Nephrology; Ontology; Patients; RNA, Messenger - genetics; Transcription factors; Transcriptome; Urine; China; microRNAs; Hub genes; IgA nephropathy; Immune cells; CIBERSORT; Immunotherapy

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, and its diagnosis depends mainly on renal biopsy. However, there is no specific treatment for IgAN. Moreover, its causes and underlying molecular events require further exploration. The expression profiles of GSE...