The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial

• Published in: Immunity & ageing Vol. 19; no. 1; pp. 46 - 11
• Main Authors: Liu, Yihao, Zhang, Hui, Yuan, Gang, Yao, Mi, Li, Bin, Chen, Jianying, Fan, Yuling, Mo, Ruohui, Lai, Fenghua, Chen, Xinwen, Li, Mengyuan, Chen, Binfeng, Lord, Janet M., Peng, Sui, Cheng, KarKeung, Xiao, Haipeng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.10.2022; BioMed Central; BMC
• Subjects: Age; Ageing; Analysis; Antibodies; Circadian; Circadian rhythm; Circadian rhythms; Clinical trials; Coronaviruses; Disease susceptibility; Gender differences; Immune response; Immunity; Immunogenicity; Influenza; Influenza vaccination; Influenza vaccines; Mortality; Older adults; Older people; Prevention; Severe acute respiratory syndrome coronavirus 2; Vaccination; Vaccines; China; Circadian; Influenza vaccination; Immunity; Older adults; Ageing

Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of the immune system suggests that adjusting the time of vaccination may provide an opportunity to improve immunogenicity. Our previous cluster trial in Birmingham suggested differences betw...