Mechanisms of reduced peak oxygen consumption in subjects with uncomplicated type 2 diabetes

• Published in: Cardiovascular diabetology Vol. 20; no. 1; pp. 124 - 13
• Main Authors: Nesti, Lorenzo, Pugliese, Nicola Riccardo, Sciuto, Paolo, De Biase, Nicolò, Mazzola, Matteo, Fabiani, Iacopo, Trico, Domenico, Masi, Stefano, Natali, Andrea
• Format: Journal Article
• Language: English
• Published: England BioMed Central 22.06.2021; BMC
• Subjects: Adult; Age; Aged; Aged, 80 and over; Anaerobic threshold; Asymptomatic; Biomarkers - blood; Blood pressure; Body mass index; Cardiopulmonary exercise test; Cardiovascular disease; Case-Control Studies; Congestive heart failure; Creatinine; Cross-Sectional Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Cardiomyopathies - diagnosis; Diabetic Cardiomyopathies - epidemiology; Diabetic Cardiomyopathies - metabolism; Diabetic Cardiomyopathies - physiopathology; Diabetic cardiomyopathy; Disease prevention; Echocardiography; Echocardiography, Stress; Effort intolerance; Ejection fraction; Electrocardiography; Exercise; Exercise physiology; Exercise Test; Exercise Tolerance; Female; Heart; Heart failure with preserved ejection fraction; Humans; Hypertension; Intolerance; Italy - epidemiology; Male; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Normal distribution; Original Investigation; Oxygen - metabolism; Oxygen Consumption; Patients; Physical fitness; Prevalence; Prospective Studies; Pulmonary arteries; Respiratory function; Skeletal muscle; Stroke Volume; Systole; Type 2 diabetes; Ventricle; Ventricular Function, Left; Italy; Japan; Germany; Heart failure with preserved ejection fraction; Type 2 diabetes; Cardiopulmonary exercise test; Diabetic cardiomyopathy; Exercise physiology; Effort intolerance

Type 2 diabetes mellitus (T2D) increases the risk of incident heart failure (HF), whose earliest fingerprint is effort intolerance (i.e. impaired peak oxygen consumption, or VO ). In the uncomplicated T2D population, however, the prevalence of effort intolerance and the underpinning mechanistic base...