Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 3; pp. 1104 - 1109
• Main Authors: Acquati, Francesco, Bertilaccio, Sabrina, Grimaldi, Annalisa, Monti, Laura, Cinquetti, Raffaella, Bonetti, Paolo, Lualdi, Marta, Vidalino, Laura, Fabbri, Marco, Sacco, Maria Grazia, van Rooijen, Nico, Campomenosi, Paola, Vigetti, Davide, Passi, Alberto, Riva, Cristina, Capella, Carlo, Sanvito, Francesca, Doglioni, Claudio, Gribaldo, Laura, Macchi, Paolo, Sica, Antonio, Noonan, Douglas M., Ghia, Paolo, Taramelli, Roberto, Klein, George
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 18.01.2011; National Acad Sciences
• Subjects: Analysis of Variance; animal ovaries; Animals; Antibodies; Biological Sciences; Cancer; carcinogenesis; Cell growth; Cell Line, Tumor; Cell lines; cellular microenvironment; Chromosomes; Data processing; Epithelial cells; Female; gene expression regulation; Genes; Genotype & phenotype; Human subjects; Humans; Immunohistochemistry; In Situ Hybridization; in vitro studies; In Vitro Techniques; lymphocytes; Macrophages; Macrophages - immunology; Malignancy; Melanoma; Mice; Mice, Nude; Microenvironments; Monocytes; Natural killer cells; Neoplasia; Oncology; Ovarian cancer; ovarian neoplasms; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; phenotype; Ribonuclease; ribonucleases; Ribonucleases - genetics; Ribonucleases - immunology; Ribonucleic acid; RNA; suppressor genes; Transcription; Tumor cell line; Tumor suppressor genes; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - immunology; Tumorigenesis; Tumors; Xenograft Model Antitumor Assays

A recent body of evidence indicates an active role for stromal (mis)-regulation in the progression of neoplasias. Within this conceptual framework, genes belonging to the growing but still poorly characterized class of tumor antagonizing/malignancy suppressor genes (TAG/MSG) seem to play a crucial r...