Measuring antigen-specific bactericidal responses to a multicomponent vaccine against serogroup B meningococcus
Serum bactericidal activity using human complement is the basis for established correlates of protection against invasive meningococcal disease. During the development of multicomponent protein-based vaccines against meningococcus B, it is necessary to measure antigen-specific bactericidal responses...
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| Published in | Vaccine Vol. 28; no. 31; pp. 5023 - 5030 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier Ltd
12.07.2010
Elsevier Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Serum bactericidal activity using human complement is the basis for established correlates of protection against invasive meningococcal disease. During the development of multicomponent protein-based vaccines against meningococcus B, it is necessary to measure antigen-specific bactericidal responses. This is not straightforward because each strain may be killed by antibodies to multiple antigens. We characterized a large panel of strains and, using a competitive inhibition SBA, we identified four strains that are each specifically killed by bactericidal antibodies to one of the major vaccine components. These strains provide a straightforward approach to demonstrate protective responses to each component of the vaccine and demonstrate that each of the antigens in the vaccine is sufficient to provide a potentially protective level of bactericidal activity. |
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| AbstractList | Serum bactericidal activity using human complement is the basis for established correlates of protection against invasive meningococcal disease. During the development of multicomponent protein-based vaccines against meningococcus B, it is necessary to measure antigen-specific bactericidal responses. This is not straightforward because each strain may be killed by antibodies to multiple antigens. We characterized a large panel of strains and, using a competitive inhibition SBA, we identified four strains that are each specifically killed by bactericidal antibodies to one of the major vaccine components. These strains provide a straightforward approach to demonstrate protective responses to each component of the vaccine and demonstrate that each of the antigens in the vaccine is sufficient to provide a potentially protective level of bactericidal activity. Abstract Serum bactericidal activity using human complement is the basis for established correlates of protection against invasive meningococcal disease. During the development of multicomponent protein-based vaccines against meningococcus B, it is necessary to measure antigen-specific bactericidal responses. This is not straightforward because each strain may be killed by antibodies to multiple antigens. We characterized a large panel of strains and, using a competitive inhibition SBA, we identified four strains that are each specifically killed by bactericidal antibodies to one of the major vaccine components. These strains provide a straightforward approach to demonstrate protective responses to each component of the vaccine and demonstrate that each of the antigens in the vaccine is sufficient to provide a potentially protective level of bactericidal activity. Serum bactericidal activity using human complement is the basis for established correlates of protection against invasive meningococcal disease. During the development of multicomponent protein-based vaccines against meningococcus B, it is necessary to measure antigen-specific bactericidal responses. This is not straightforward because each strain may be killed by antibodies to multiple antigens. We characterized a large panel of strains and, using a competitive inhibition SBA, we identified four strains that are each specifically killed by bactericidal antibodies to one of the major vaccine components. These strains provide a straightforward approach to demonstrate protective responses to each component of the vaccine and demonstrate that each of the antigens in the vaccine is sufficient to provide a potentially protective level of bactericidal activity.Serum bactericidal activity using human complement is the basis for established correlates of protection against invasive meningococcal disease. During the development of multicomponent protein-based vaccines against meningococcus B, it is necessary to measure antigen-specific bactericidal responses. This is not straightforward because each strain may be killed by antibodies to multiple antigens. We characterized a large panel of strains and, using a competitive inhibition SBA, we identified four strains that are each specifically killed by bactericidal antibodies to one of the major vaccine components. These strains provide a straightforward approach to demonstrate protective responses to each component of the vaccine and demonstrate that each of the antigens in the vaccine is sufficient to provide a potentially protective level of bactericidal activity. |
| Author | Oster, Philipp Pizza, Mariagrazia Donnelly, John Serruto, Davide Vienken, Kay Biolchi, Alessia Rappuoli, Rino Ferlicca, Francesca Giuliani, Marzia M. |
| Author_xml | – sequence: 1 givenname: Marzia M. surname: Giuliani fullname: Giuliani, Marzia M. organization: Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy – sequence: 2 givenname: Alessia surname: Biolchi fullname: Biolchi, Alessia organization: Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy – sequence: 3 givenname: Davide surname: Serruto fullname: Serruto, Davide organization: Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy – sequence: 4 givenname: Francesca surname: Ferlicca fullname: Ferlicca, Francesca organization: Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy – sequence: 5 givenname: Kay surname: Vienken fullname: Vienken, Kay organization: Novartis Vaccines and Diagnostics, Emil-von-Behringstrasse 76, Marburg 35041, Germany – sequence: 6 givenname: Philipp surname: Oster fullname: Oster, Philipp organization: Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy – sequence: 7 givenname: Rino surname: Rappuoli fullname: Rappuoli, Rino organization: Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy – sequence: 8 givenname: Mariagrazia surname: Pizza fullname: Pizza, Mariagrazia organization: Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy – sequence: 9 givenname: John surname: Donnelly fullname: Donnelly, John email: john.donnelly_iii@novartis.com organization: Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy |
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| Copyright | 2010 Elsevier Ltd Elsevier Ltd 2015 INIST-CNRS Copyright 2010 Elsevier Ltd. All rights reserved. Copyright Elsevier Limited Jul 12, 2010 Copyright 2010 Elsevier Ltd. All rights reserved. |
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| Keywords | MenB vaccine Serum bactericidal activity Neisseria meningitidis Antigen Neisseriaceae Bacteria Micrococcales Serum Vaccine |
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