Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam

• Published in: PloS one Vol. 4; no. 3; p. e4800
• Main Authors: Nguyen, Thi Hue, Mai, Ngoc Lanh, Le, Thi Phuong, Ha, Vinh, Nguyen, Tran Chinh, Tran, Tinh Hien, Nguyen, T Hieu, Farrar, Jeremy J, Dunstan, Sarah J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.03.2009; Public Library of Science (PLoS)
• Subjects: Alleles; Bacteria; Burns; Case-Control Studies; Clinical medicine; Cytokines; Deoxyribonucleic acid; Disease susceptibility; DNA; DNA Mutational Analysis; Drug development; Endotoxins; Ethnic Groups - genetics; Exons - genetics; Female; Fever; Gene expression; Gene Frequency; Genes; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease; Genetic variance; Genetics and Genomics/Genetics of Disease; Genotype; Genotyping; Health aspects; Hospitals; Humans; Immune response; Immune system; Immunology/Immunity to Infections; Immunology/Innate Immunity; Infections; Infectious diseases; Infectious Diseases/Bacterial Infections; Innate immunity; Legionnaires disease; Male; Medicine; Meningitis; Missense mutation; Mutation; Mutation, Missense; Pathogenesis; Patients; Polymorphism, Single Nucleotide; Promoter Regions, Genetic - genetics; Protein Structure, Tertiary; Proteins; Salmonella; Salmonella Typhimurium; Sepsis; Single-nucleotide polymorphism; Studies; TLR4 protein; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - physiology; Toll-like receptors; Transcription factors; Tropical diseases; Typhoid; Typhoid fever; Typhoid Fever - epidemiology; Typhoid Fever - genetics; Vaccines; Vietnam - epidemiology; Waterborne diseases; Vietnam

Understanding the host genetic susceptibility to typhoid fever may provide a better understanding of pathogenesis and help in the development of new therapeutics and vaccines. Here we determine the genetic variation within the human TLR4 gene encoding the principal receptor for bacterial endotoxin r...