Triclosan activates c-Jun/miR-218-1-3p/SLC35C1 signaling to regulate cell viability, migration, invasion and inflammatory response of trophoblast cells in vitro

• Published in: BMC pregnancy and childbirth Vol. 22; no. 1; pp. 470 - 11
• Main Authors: Huo, Weiwei, Wang, Ying, Chen, Ting, Cao, Tianyue, Zhang, Yue, Shi, Zhouhong, Hou, Shunyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central 06.06.2022; BMC
• Subjects: Abortion, Spontaneous - genetics; Antibodies; Binding sites; Cell Movement - genetics; Cell Proliferation - genetics; Cell Survival; Female; Gene expression; Humans; Inflammatory response; Lymphocytes; MicroRNAs - genetics; MicroRNAs - metabolism; Migration; miR-218-1-3p; Miscarriage; Monosaccharide Transport Proteins - metabolism; Pregnancy; Proteins; SLC35C1; Triclosan; Triclosan - metabolism; Triclosan - pharmacology; Trophoblast cells; Trophoblasts - metabolism; Womens health; Wound healing; United States > US; China; Inflammatory response; Triclosan; SLC35C1; Trophoblast cells; miR-218-1-3p

Spontaneous abortion is considered as the commonest complication of pregnancy. Triclosan (TCS) is an antimicrobial agent, which participates in the process of multiple human diseases, including spontaneous abortion. Our study aimed to evaluate the effect of TCS on spontaneous abortion and disclose t...