circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis

• Published in: Molecular cancer Vol. 20; no. 1; pp. 169 - 21
• Main Authors: Gui, Cheng-Peng, Liao, Bing, Luo, Cheng-Gong, Chen, Yu-Hang, Tan, Lei, Tang, Yi-Ming, Li, Jia-Ying, Hou, Yi, Song, Hong-De, Lin, Hai-Shan, Xu, Quan-Hui, Yao, Gao-Sheng, Yao, Hao-Hua, Xi-Liu, Luo, Jun-Hang, Cao, Jia-Zheng, Wei, Jin-Huan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.12.2021; BioMed Central; BMC
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adult; Aged; Animals; Biomarkers; Biomarkers, Tumor; Breast cancer; Carcinoma, Renal cell; Carcinoma, Renal Cell - diagnosis; Carcinoma, Renal Cell - genetics; Cell culture; Cell Cycle Proteins - genetics; Cell growth; Cell Line, Tumor; Cell proliferation; Clear cell renal cell carcinoma; Clear cell-type renal cell carcinoma; Development and progression; Disease Models, Animal; DNA microarrays; EIF4EBP1; Female; Fluorescence in situ hybridization; Gel electrophoresis; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Heterografts; hsa_circ_0020303; Humans; Kidney cancer; Kidney Neoplasms - diagnosis; Kidney Neoplasms - genetics; Kidneys; Male; Medical prognosis; Membrane Glycoproteins - genetics; Metastases; Metastasis; Mice; MicroRNA; MicroRNAs - genetics; Middle Aged; Mineral industry; Mining industry; miR-125a-5p; miRNA; Models, Biological; Neoplasm Grading; Neoplasm Staging; Patients; Plasmids; Polymerase chain reaction; Prognosis; Proliferation; RNA Interference; RNA, Circular; Sulfotransferases - genetics; Therapeutic targets; Tumors; Wound healing; China; EIF4EBP1; hsa_circ_0020303; Clear cell renal cell carcinoma; Metastasis; Proliferation; miR-125a-5p

Circular RNAs (circRNAs) have been indicated as potentially critical mediators in various types of tumor progression, generally acting as microRNA (miRNA) sponges to regulate downstream gene expression. However, the aberrant expression profile and dysfunction of circRNAs in human clear cell renal ce...