Association of FBN1 polymorphism with susceptibility of adolescent idiopathic scoliosis: a case-control study

• Published in: BMC musculoskeletal disorders Vol. 23; no. 1; pp. 430 - 8
• Main Authors: de Azevedo, Gustavo Borges Laurindo, Perini, Jamila Alessandra, Araújo Junior, Antônio Eulálio Pedrosa, Moliterno, Luis Antonio Medeiros, Andrande, Rodrigo Mantelatto, Guimarães, João Antonio Matheus, Defino, Helton Luiz Aparecido
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.05.2022; BioMed Central; BMC
• Subjects: Adolescent; Adolescent idiopathic scoliosis; Age; Analysis; Biomechanics; Body mass index; Care and treatment; Case-Control Studies; Confidence intervals; Connective tissue; Diagnosis; Disease susceptibility; Extracellular matrix; Female; Fibrillin; Fibrillin-1; Fibrillin-1 - genetics; Gene polymorphism; Genes; Genetic polymorphisms; Genome-wide association studies; Humans; Male; Methods; Microfibrils; Musculoskeletal diseases; Pathogenesis; Patients; Polymorphism; Polymorphism, Single Nucleotide; Population; Risk factors; Scoliosis; Scoliosis - diagnostic imaging; Scoliosis - genetics; Severity of Illness Index; Sociodemographics; Statistical analysis; Susceptibility; Teenagers; Testing; Thermal cycling; Brazil; United States > US; Fibrillin-1; Adolescent idiopathic scoliosis; Polymorphism
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-022-05370-1

Fibrillin-1 (FBN1) is an extracellular matrix glycoprotein essential to the structural component of microfibrils and FBN1 gene polymorphisms can be associated with adolescent idiopathic scoliosis (AIS) susceptibility. This study aimed to evaluate the potential role of the FBN1 rs12916536 polymorphis...