CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine

• Published in: British journal of clinical pharmacology Vol. 41; no. 6; pp. 605 - 608
• Main Authors: CARRILLO, JUAN A., BENITEZ, JULIO
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Science Ltd 01.06.1996; Blackwell Science
• Subjects: Adult; Arylamine N-Acetyltransferase - urine; Biological and medical sciences; caffeine; Caffeine - toxicity; Caffeine - urine; CYP1A2 activity; Cytochrome P-450 CYP1A2 - metabolism; Dealkylation; Female; gender; Humans; Male; Medical sciences; Neuropharmacology; Original; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Sex Factors; Smoking; toxicity; Xanthine Oxidase - urine; Human; Drug; Urine; CNS stimulant; Isozyme; Metabolite; Toxicity; Cytochrome P450; Stimulative beverage; Sex; Tobacco smoking; Oral administration; Metabolism; Normal; Respiratory analeptic; Xanthine derivatives; Drug poison interaction; Caffeine

We have investigated several factors that might be related to the occurrence of toxic effects during the performance of a urinary test with caffeine (300 mg p.o), in 120 healthy volunteers. A total of 218 toxic effects were self‐reported by eighty‐two (68%) subjects. Females and nonsmokers were at t...