Genetic background influences arterial vasomotor function in male and female mice
The purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)‐mediated vasomotor function in arteries from different vascular territories. Vasomotor function was assessed in thoracic aorta, abdominal aorta, carotid arteries, and femoral arteries from the fo...
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Published in | Physiological reports Vol. 11; no. 19; pp. e15824 - n/a |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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John Wiley & Sons, Inc
01.10.2023
John Wiley and Sons Inc Wiley |
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Abstract | The purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)‐mediated vasomotor function in arteries from different vascular territories. Vasomotor function was assessed in thoracic aorta, abdominal aorta, carotid arteries, and femoral arteries from the following mouse strains: SJL/J, DBA/2J, NZW/LacJ, and C57BL/6J. Contractile responses were assessed using the α1‐adrenergic receptor agonist phenylephrine (PE, 10−9–10−5 M). Vasorelaxation responses were assessed by examining relaxation to an endothelium‐dependent vasodilator acetylcholine (ACh, 10−9–10−5 M) and an endothelium‐independent vasodilator sodium nitroprusside (SNP, 10−9–10−5 M). To evaluate the role of NO, relaxation responses to ACh and SNP were assessed in the absence or presence of a nitric oxide synthase inhibitor (N omega‐nitro‐l‐arginine methyl ester hydrochloride: 10−4 M). Vasomotor responses to ACh and PE varied across strains and among the arteries tested with some strains exhibiting artery‐specific impairment. Results indicated some concentration–response heterogeneity in response to ACh and SNP between vessels from females and males, but no significant differences in responses to PE. Collectively, these findings indicate that vasomotor responses vary by genetic background, sex, and artery type. |
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AbstractList | The purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)-mediated vasomotor function in arteries from different vascular territories. Vasomotor function was assessed in thoracic aorta, abdominal aorta, carotid arteries, and femoral arteries from the following mouse strains: SJL/J, DBA/2J, NZW/LacJ, and C57BL/6J. Contractile responses were assessed using the α1-adrenergic receptor agonist phenylephrine (PE, 10−9–10−5 M). Vasorelaxation responses were assessed by examining relaxation to an endothelium-dependent vasodilator acetylcholine (ACh, 10−9–10−5 M) and an endothelium-independent vasodilator sodium nitroprusside (SNP, 10−9–10−5 M). To evaluate the role of NO, relaxation responses to ACh and SNP were assessed in the absence or presence of a nitric oxide synthase inhibitor (N omega-nitro-l-arginine methyl ester hydrochloride: 10−4 M). Vasomotor responses to ACh and PE varied across strains and among the arteries tested with some strains exhibiting artery-specific impairment. Results indicated some concentration–response heterogeneity in response to ACh and SNP between vessels from females and males, but no significant differences in responses to PE. Collectively, these findings indicate that vasomotor responses vary by genetic background, sex, and artery type. Abstract The purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)‐mediated vasomotor function in arteries from different vascular territories. Vasomotor function was assessed in thoracic aorta, abdominal aorta, carotid arteries, and femoral arteries from the following mouse strains: SJL/J, DBA/2J, NZW/LacJ, and C57BL/6J. Contractile responses were assessed using the α1‐adrenergic receptor agonist phenylephrine (PE, 10−9–10−5 M). Vasorelaxation responses were assessed by examining relaxation to an endothelium‐dependent vasodilator acetylcholine (ACh, 10−9–10−5 M) and an endothelium‐independent vasodilator sodium nitroprusside (SNP, 10−9–10−5 M). To evaluate the role of NO, relaxation responses to ACh and SNP were assessed in the absence or presence of a nitric oxide synthase inhibitor (N omega‐nitro‐l‐arginine methyl ester hydrochloride: 10−4 M). Vasomotor responses to ACh and PE varied across strains and among the arteries tested with some strains exhibiting artery‐specific impairment. Results indicated some concentration–response heterogeneity in response to ACh and SNP between vessels from females and males, but no significant differences in responses to PE. Collectively, these findings indicate that vasomotor responses vary by genetic background, sex, and artery type. The purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)‐mediated vasomotor function in arteries from different vascular territories. Vasomotor function was assessed in thoracic aorta, abdominal aorta, carotid arteries, and femoral arteries from the following mouse strains: SJL/J, DBA/2J, NZW/LacJ, and C57BL/6J. Contractile responses were assessed using the α1‐adrenergic receptor agonist phenylephrine (PE, 10 −9 –10 −5 M). Vasorelaxation responses were assessed by examining relaxation to an endothelium‐dependent vasodilator acetylcholine (ACh, 10 −9 –10 −5 M) and an endothelium‐independent vasodilator sodium nitroprusside (SNP, 10 −9 –10 −5 M). To evaluate the role of NO, relaxation responses to ACh and SNP were assessed in the absence or presence of a nitric oxide synthase inhibitor ( N omega‐nitro‐ l ‐arginine methyl ester hydrochloride: 10 −4 M). Vasomotor responses to ACh and PE varied across strains and among the arteries tested with some strains exhibiting artery‐specific impairment. Results indicated some concentration–response heterogeneity in response to ACh and SNP between vessels from females and males, but no significant differences in responses to PE. Collectively, these findings indicate that vasomotor responses vary by genetic background, sex, and artery type. |
Author | Woodman, Christopher R. Massett, Michael P. Holly, Dylan Kim, Hyoseon |
AuthorAffiliation | 2 Department of Kinesiology and Sport Management Texas Tech University Lubbock Texas USA 1 Department of Kinesiology and Sport Management Texas A&M University College Station Texas USA |
AuthorAffiliation_xml | – name: 2 Department of Kinesiology and Sport Management Texas Tech University Lubbock Texas USA – name: 1 Department of Kinesiology and Sport Management Texas A&M University College Station Texas USA |
Author_xml | – sequence: 1 givenname: Dylan orcidid: 0000-0002-3551-6088 surname: Holly fullname: Holly, Dylan organization: Texas A&M University – sequence: 2 givenname: Hyoseon orcidid: 0000-0001-8933-6042 surname: Kim fullname: Kim, Hyoseon organization: Texas Tech University – sequence: 3 givenname: Christopher R. orcidid: 0000-0002-2700-5077 surname: Woodman fullname: Woodman, Christopher R. email: woodmanc@tamu.edu organization: Texas A&M University – sequence: 4 givenname: Michael P. orcidid: 0000-0001-5356-4959 surname: Massett fullname: Massett, Michael P. email: mmassett@ttu.edu organization: Texas Tech University |
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Snippet | The purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)‐mediated vasomotor function in arteries from different... The purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)-mediated vasomotor function in arteries from different... Abstract The purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)‐mediated vasomotor function in arteries from... |
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SubjectTerms | Adrenergic receptors Age Aorta Arginine Atherosclerosis Blood vessels Cardiovascular disease Carotid artery Contractility Coronary vessels Endothelium Females Femoral artery Gender differences inbred mice Laboratory animals Males NG-Nitroarginine methyl ester Nitric oxide Nitric-oxide synthase Original Phenylephrine Physiology sex differences Single-nucleotide polymorphism Sodium nitroprusside Thorax Vasodilation Vasodilators Veins & arteries |
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Title | Genetic background influences arterial vasomotor function in male and female mice |
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