Smoking and risk for amyotrophic lateral sclerosis: Analysis of the EPIC cohort

• Published in: Annals of neurology Vol. 65; no. 4; pp. 378 - 385
• Main Authors: Gallo, Valentina, Bueno-De-Mesquita, H. Bas, Vermeulen, Roel, Andersen, Peter M., Kyrozis, Andreas, Linseisen, Jakob, Kaaks, Rudolph, Allen, Naomi E., Roddam, Andrew W., Boshuizen, Hendriek C., Peeters, Petra H., Palli, Domenico, Mattiello, Amalia, Sieri, Sabina, Tumino, Rosario, Jiménez-Martín, Juan-Manuel, Tormo Díaz, María José, Rodriguez Suarez, Laudina, Trichopoulou, Antonia, Agudo, Antonio, Arriola, Larraitz, Barricante-Gurrea, Aurelio, Bingham, Sheila, Khaw, Kay-Tee, Manjer, Jonas, Lindkvist, Björn, Overvad, Kim, W. Bach, Flemming, Tjønneland, Anne, Olsen, Anja, Bergmann, Manuela M., Boeing, Heiner, Clavel-Chapelon, Francoise, Lund, Eiliv, Hallmans, Göran, Middleton, Lefkos, Vineis, Paolo, Riboli, Elio
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2009; Wiley-Liss
• Subjects: Adult; Age Factors; Aged; Amyotrophic Lateral Sclerosis - epidemiology; Amyotrophic Lateral Sclerosis - etiology; Amyotrophic Lateral Sclerosis - mortality; Biological and medical sciences; Clinical Medicine; Cohort Studies; Europe - epidemiology; Female; Humans; International Cooperation; Kirurgi; Klinisk medicin; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Proportional Hazards Models; Risk; Sex Factors; Smoking - adverse effects; Surgery; Surveys and Questionnaires; Europe; Nervous system diseases; Central nervous system disease; Tobacco smoking; Amyotrophic lateral sclerosis; Degenerative disease; Risk analysis; Spinal cord disease

Objective Cigarette smoking has been reported as “probable” risk factor for Amyotrophic Lateral Sclerosis (ALS), a poorly understood disease in terms of aetiology. The extensive longitudinal data of the European Prospective Investigation into Cancer and Nutrition (EPIC) were used to evaluate age‐spe...