Exploitation of glycosylation in enveloped virus pathobiology

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 10; pp. 1480 - 1497
• Main Authors: Watanabe, Yasunori, Bowden, Thomas A., Wilson, Ian A., Crispin, Max
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2019; The Author(s). Published by Elsevier B.V
• Subjects: animal pathogens; Dengue virus; Ebolavirus; Glycan shielding; glycomics; Glycoprotein; Glycoproteins - metabolism; Glycosylation; Host-Pathogen Interactions; Human immunodeficiency virus 1; Humans; Immune Evasion; Lassa mammarenavirus; Molecular Mimicry; oligosaccharides; Orthomyxoviridae; parasites; pathogenesis; polysaccharides; Polysaccharides - metabolism; Protein Folding; Protein Transport; Structure; vaccines; viral envelope proteins; Virus; Virus Physiological Phenomena; Virus-host interactions; viruses; Viruses - immunology; Viruses - metabolism; Zika virus; Virus; Glycosylation; Structure; Glycan shielding; Virus-host interactions; Glycoprotein

Glycosylation is a ubiquitous post-translational modification responsible for a multitude of crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to glycosylate their own proteins during replication. Viral envelope proteins from a variety of human pathogens including...