Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

• Published in: Molecular cell Vol. 57; no. 3; pp. 537 - 551
• Main Authors: Kashatus, Jennifer A., Nascimento, Aldo, Myers, Lindsey J., Sher, Annie, Byrne, Frances L., Hoehn, Kyle L., Counter, Christopher M., Kashatus, David F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.02.2015
• Subjects: adenocarcinoma; Animals; Benzamides - pharmacology; Cell Line, Tumor; Diphenylamine - analogs & derivatives; Diphenylamine - pharmacology; Gene Knockdown Techniques; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; guanosinetriphosphatase; HEK293 Cells; HeLa Cells; Humans; Mice; Mice, Nude; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; mitochondria; Mitochondrial Dynamics - drug effects; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; mitogen-activated protein kinase; Mitogen-Activated Protein Kinase 1 - metabolism; Neoplasms, Experimental - metabolism; pancreatic neoplasms; Pancreatic Neoplasms - metabolism; phenotype; Phosphorylation; ras Proteins - metabolism; serine; Serine - metabolism

Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of downstream effectors that promote a tumorigenic phenotype. As targeting Ras directly is difficult, there is a significant effort to unde...